Low-frequency High-Intensity Interval Training in Overweight or Obese Young Adults
- Conditions
- Overweight and Obesity
- Interventions
- Behavioral: Exercise intervention
- Registration Number
- NCT03904810
- Lead Sponsor
- The University of Hong Kong
- Brief Summary
Background: The relationship between the frequency of high-intensity interval training (HIIT) and the resultant adaptations is largely unclear. Purpose: This study examined the effects of different frequencies of HIIT compared to moderate-intensity continuous training (MICT) on body composition and cardiovascular biomarkers in overweight or obese adults. Methods: This study was a randomized, controlled, single-blinded trial. Fifty-six overweight or obese men aged between 18 and 30 years were randomly assigned to no-intervention control (CON; n=14), MICT performed thrice weekly (MICT×3/wk; n=9), HIIT performed thrice weekly (HIIT×3/wk; n=14), HIIT performed twice weekly (HIIT×2/wk; n=10), and HIIT performed once weekly (HIIT×1/wk; n=9). Each HIIT session consisted of 12 × 1-min bouts at 90% heart rate reserve (HRR), interspersed with 11 × 1-min bouts at 70% HRR (HIIT×3/wk: 69 min/wk; HIIT×2/wk: 46 min/wk; HIIT×1/wk: 23 min/wk). Aerobic capacity, resting heart rate, body composition, waist circumference, blood pressure, endothelial function, fasting blood glucose and lipids, circulatory adipokines and inflammatory biomarkers were examined at baseline, after 4 weeks and 8 weeks of intervention.
- Detailed Description
Individuals who fulfilled the following inclusion criteria were invited to participate in the present study: 1) Chinese male; 2) aged 18-30 years; and 3) overweight or obesity, defined as BMI ≥23 kg/m2 (classification of overweight for Hong Kong adults according to Department of Health, Hong Kong SAR Government) (13). Subjects were excluded if they had: 1) chronic medical and health condition such as cardiovascular diseases, diabetes, neurological disease, musculoskeletal disorder, cancers, and autoimmune diseases; 2) hypertension (blood pressure \>140/90 mmHg); 3) contraindications to participating in physical exercise; 4) any pre-existing medical or physical issues that affected the experimental test; 5) physically active (i.e., \>3 hours of moderate-intensity exercise weekly) or 6) lean overweight population (BMI ≥23 kg/m2, but percent body fat ≤20%) according to the BMI data corresponding to bioelectrical impedance estimated percent body fat cut-off value among Hong Kong Chinese adults.
Of those who were screened, 103 Chinese young adults were eligible to participate in this study. They were provided with written and verbal information on the study protocol and the possible associated discomforts and risks followed by obtaining their written informed consent to participate in this study. The study protocol and consent form were approved by the Human Subjects Ethics Sub-Committee of The Hong Kong Polytechnic University (ethics approval reference number: HSEARS20160927005-01).
This study was a single-blind, randomized, controlled trial. Subjects were randomly assigned to 1) no-intervention control (CON), 2) MICT performed thrice weekly (MICTx3/wk), 3) HIIT performed thrice weekly (HIITx3/wk), 4) twice weekly (HIITx2/wk), and 5) once weekly (HIITx1/wk). All subjects were instructed to maintain their usual daily activities. Outcome measures including aerobic capacity, body composition, blood pressure, resting heart rate, endothelial function, arterial stiffness, fasting glucose, lipids markers, adipokine marker, and inflammatory marker were assessed at baseline, 4 weeks and 8 weeks after the intervention.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 103
- Chinese male
- Aged 18-30 years
- Overweight or obesity, defined as BMI ≥23 kg/m2 (classification of overweight for Hong Kong adults according to Department of Health, Hong Kong SAR Government)
- Chronic medical and health condition such as cardiovascular diseases, diabetes, neurological disease, musculoskeletal disorder, cancers, and autoimmune diseases
- Hypertension (blood pressure >140/90 mmHg)
- Contraindications to participating in physical exercise
- Any pre-existing medical or physical issues that affected the experimental test
- Physically active (i.e., >3 hours of moderate-intensity exercise weekly)
- Lean overweight population (BMI ≥23 kg/m2, but percent body fat ≤20%) according to the BMI data corresponding to bioelectrical impedance estimated percent body fat cut-off value among Hong Kong Chinese adults.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description High Intensity Interval Training×3/wk Exercise intervention Subjects in this group will receive three sessions of High-Intensity Interval Training per week throughout the 8 weeks experimental period Moderate Intensity Continuous Training ×3/wk Exercise intervention Subjects in this group will receive three sessions of Moderate-Intensity Continuous Training per week throughout the 8 weeks experimental period High Intensity Interval Training×1/wk Exercise intervention Subjects in this group will receive one session of High-Intensity Interval Training per week throughout the 8 weeks experimental period High Intensity Interval Training×2/wk Exercise intervention Subjects in this group will receive two session of High-Intensity Interval Training per week throughout the 8 weeks experimental period
- Primary Outcome Measures
Name Time Method Body weight 8 weeks Body weight in kg were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).
Total running distance 8 weeks Total running distance in meters achieved during the 20-meter shuttle multistage run test were used for the assessment of aerobic fitness
Total fat-free mass 8 weeks Total body fat-free mass were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).
Total body fat mass 8 weeks Total body fat mass in kg were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).
Total body fat-free mass percentage 8 weeks Total body fat-free mass percentage were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).
Total body fat percentage 8 weeks Total body fat percentage were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).
Body height 8 weeks Body height in meter were assessed.
Estimated maximal oxygen consumption 8 weeks Estimated maximal oxygen consumption achieved during the 20-meter shuttle multistage run test were used for the assessment of aerobic fitness Unit: body weight, estimated oxygen consumption and minute will be combined to report the estimated VO2max in ml/kg/min.
Trunk fat mass 8 weeks Trunk fat mass in kg were assessed by a bioelectrical impedance analyzer (BC-418, Tanita, Japan).
Body mass index (BMI) 8 weeks Weight and height will be combined to report BMI in kg/m\^2
Waist circumference 8 weeks Waist circumference was determined to the nearest 0.1 cm of a contact tension tape. The tape was applied directly to the skin at the mid-point between the lower margin of the last palpable rib and the top of the iliac crest.
- Secondary Outcome Measures
Name Time Method Diastolic blood pressure 8 weeks Diastolic blood pressure was determined by an electronic sphygmomanometer (Accutorr Plus, Datascope, USA)
Mean arterial pressure 8 weeks Mean arterial pressure was determined by an electronic sphygmomanometer (Accutorr Plus, Datascope, USA)
Resting heart rate 8 weeks Resting heart rate was determined by an electronic sphygmomanometer (Accutorr Plus, Datascope, USA)
Interleukin 6 8 weeks Commercially available enzyme-linked immunosorbent assay kits (R\&D systems, Minneapolis, MN) were used to determine interleukin 6
Tumor necrosis factor alpha 8 weeks Commercially available enzyme-linked immunosorbent assay kits (R\&D systems, Minneapolis, MN) were used to determine tumor necrosis factor alpha
Endothelial function 8 weeks Endothelial function were measured by digital plethysmography using EndoPAT 2000 device (ITAMAR Medical, Caesarea, Israel) and expressed as natural log reactive hyperemia index (LnRHI)
Systolic blood pressure 8 weeks Systolic blood pressure was determined by an electronic sphygmomanometer (Accutorr Plus, Datascope, USA)
Arterial stiffness 8 weeks Arterial stiffness were measured by digital plethysmography using EndoPAT 2000 device (ITAMAR Medical, Caesarea, Israel) and expressed as augmentation index normalized to heart rate of 75 bpm (AI@75)
Serum fasting glucose 8 weeks Fresh blood samples were sent to an accredited medical laboratory to measure the serum fasting glucose concentrations by commercial test kit methods with an automatic clinical chemistry analyzer (Architect CI8200, Abbott Diagnostics, USA)
Triglycerides 8 weeks Fresh blood samples were sent to an accredited medical laboratory to measure the serum triglycerides concentrations by commercial test kit methods with an automatic clinical chemistry analyzer (Architect CI8200, Abbott Diagnostics, USA)
High-density lipoproteins (HDL) cholesterol 8 weeks Fresh blood samples were sent to an accredited medical laboratory to measure the serum high-density lipoproteins-cholesterol (HDL-C) concentrations by commercial test kit methods with an automatic clinical chemistry analyzer (Architect CI8200, Abbott Diagnostics, USA)
Low-density lipoprotein (LDL) cholesterol 8 weeks Low-density lipoprotein (LDL) cholesterol in serum was measured by an automatic chemistry analyzer (AU-480, Beckman Coulter, USA)
C-reactive protein 8 weeks Commercially available enzyme-linked immunosorbent assay kits (R\&D systems, Minneapolis, MN) were used to determine c-reactive protein
Adiponectin 8 weeks Commercially available enzyme-linked immunosorbent assay kits (R\&D systems, Minneapolis, MN) were used to determine adiponectin
Intercellular adhesion molecule-1 8 weeks Commercially available enzyme-linked immunosorbent assay kits (R\&D systems, Minneapolis, MN) were used to determine intercellular adhesion molecule-1
Vascular cell adhesion molecule-1 8 weeks Commercially available enzyme-linked immunosorbent assay kits (R\&D systems, Minneapolis, MN) were used to determine vascular cell adhesion molecule-1
Trial Locations
- Locations (1)
LKS Faculty of Medicine
🇭🇰Hong Kong, Hong Kong