The role of skeletal muscle and determinants of Altered Pain threshold responses with acute Resistance Exercise in knee osteoarthrits(The AsPIRE study)

niversity of Sydney0 个研究点目标入组 48 人开始时间: 2018年6月8日最近更新: 2019年7月15日

适应症

试验速览

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•1.For the early knee OA group, subjects should be diagnosed as having knee OA using the Kellgren-Lawrence grade(KLG) grade, with KLG 1-2 as a criteria on plain radiograph of the knee.
•2.For the late knee OA group, subjects should be diagnosed as having knee OA using the Kellgren-Lawrence grade (KLG) grade, with KLG 4 as a criteria on plain radiograph of the knee. The additional criteria for participants in the late knee OA group is that they should be scheduled for total knee arthroplasty
•3.Able to complete questionnaires in English
•4.Able and willing to complete study assessments
•5.Able and willing to provide written consent to participate in the study

•Documented history of systemic inflammatory or autoimmune diseases
•Documented history of skeletal muscle pathological diseases such as myopathies and myositis
•History of diabetes, significant cardiovascular, neurological or psychiatric disease, cervical or lumbar root compression syndromes and widespread regional pain syndromes (e.g. fibromyalgia)
•History of lower extremity joint replacement in the study limb
•Women who are pregnant or lactating or of child-bearing potential who are not willing to avoid pregnancy during the study period
•Systolic Blood pressure > 200mmHg and / or diastolic blood pressure > 120mmHg
•Current use of oral steroid medications
•Unable to discontinue non-steroidal anti-inflammatory medication use

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