Identificación de biomarcadores proteicos asociados a resistencia a la aspirina y a tienopiridinas en pacientes con cardiopatía isquémica establecida. (ESTUDIO BIRAT).Identification of new protein biomarkers associated with aspirin and thienopyridine resistance in stable coronary ischaemic patients: a proteomic study. (BIRAT Study). - BIRAT

• Conditions: To determine proteins in plasma, leukocytes and platelets associated with aspirin resistance syndrome in stable coronary artery disease patients that may allow us to identify them.It is probably that may also exist proteins that allows us to identify thienopyridine resistanceIdentificar en plasma, leucocitos y plaquetas proteínas asociadas con resistencia a aspirina en pacientes con enfermedad coronaria estable.Podrían existir proteínas que nos permitan identificar resistencia a tienopiridinas

• Registration Number: EUCTR2007-006686-32-ES
• Lead Sponsor: FUNDACIÓN INVESTIGACIÓN BIOMEDICA DEL HOSPITAL CLINICO SAN CARLOS

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-03-27
• Last Update Posted: 19 March 2012

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

-Men and women, ages 18 or older
-Documented history of coronary disease define as >50% stenosis in >/= 1 major coronary artery, clinically stable for at least 6 months.
-Stable clinical situation at least during the last month.
-Patients receiving AAS 100 mg daily at least during the last month and with the last AAS dosage 24 hours before
-Written consent
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

-Another antithrombotic treatment than AAS in the previous month
-Presence of active infectious or tumoral disease
-Recent trauma or major surgery, angioplasty or cathetherism during the last month
-Atorvastatin treated patients
-Patients receiving antiinflammatory treatment during the last month
-No written consent

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified