Changes in arterial and end tidal carbon dioxide levels before and after fluid resuscitation in septic shock patients admitted in ICU

Not yet recruiting

• Conditions: Sepsis, unspecified organism,

• Registration Number: CTRI/2021/11/038170
• Lead Sponsor: PGIMER

Brief Summary

The primary purpose of the study is to determine changes in arterial PCO2 and end-tidal carbon dioxide pre and post resuscitation in septic shock patients admitted in ICU. The hypothesis is that the arterial PCO2 and EtCO2 change after volume resuscitation with changes in the gap between the two.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-11-17
• Study Start: 2021-11-25

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

all patients with age > 18 years admitted in intensive care unit with septic shock.

Exclusion Criteria

patients who refuse to participate in the study and patients having conditions affecting lung permeability like interstitial lung disease, idiopathic pulmonary fibrosis, severe bronchial asthma ,COPD, or cardiovascular conditions like congenital heart disease, valvular heart disease, cardiomyopathy having baseline LVEF< 30% , h/o pulmonary embolism, bronchopleural fistula, extracorporeal life support.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
changes in arterial PCO2 and end- tidal carbon dioxide (EtCO2) pre and post resuscitation in septic shock patients	At 0 hour, 1 hour and 6 hours of resuscitation

Secondary Outcome Measures

Name	Time	Method
correlation between central venous-arterial PCO2 (∆PCO2) gap and arterial PCO2-EtCO2 (A-E) CO2 gap in all the patients	At 0 hour, 1 hour and 6 hours of resuscitation
correlation between these two gaps in critically ill septicemic patients in the context of extent of fluid requirement, extent of inotrope requirement, extent of organ damage (SOFA score) and ICU mortality

Trial Locations

Locations (1)

PGIMER, Chandigarh; 🇮🇳 Chandigarh, CHANDIGARH, India

PGIMER, Chandigarh

🇮🇳Chandigarh, CHANDIGARH, India

Dr Ravi Kant Dogra

Principal investigator

9418465978

drravikantdogra@gmail.com