Assessing Gene-Environment Interactions in Clinical Presentation of Nevi and Melanoma
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Nevi and Melanomas
- Sponsor
- University of Colorado, Denver
- Enrollment
- 71
- Locations
- 1
- Primary Endpoint
- UV Exposure Assessment
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This research study is designed to better understand the role of genetics, sun-exposure and phenotypic factors in melanoma.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\> or = 18 years of age
- •Patient at the University of Colorado Anschutz Medical Campus Cutaneous Oncology Clinic or Dermatology Clinic OR attend the fundraising event of the Colorado Melanoma Foundation
Exclusion Criteria
- •No exclusion criteria listed
Outcomes
Primary Outcomes
UV Exposure Assessment
Time Frame: Start of study to end of study, up to 6 weeks
Identify the difference between self-reported sun exposure behavior and actual UV exposure by having patients wear individual dosimeters
Visual Appearance Relationships: Non-Melanoma, SCINEXA
Time Frame: Start of study to end of study, up to 3 years
Determine the relationship between UV camera score, skin patch, sun exposure history, and phenotypic evaluation in non-melanoma patients using a SCINEXA exam.
Sun Exposure Behaviors
Time Frame: Start of study, initial interaction with participants.
A short questionnaire is administered during the clinic visit to assess sun exposure behaviors of melanoma patients. The data gathered from this questionnaire will help identify possible trends in sun exposure behaviors and provide a baseline dataset for future research,
Visual Appearance Relationships: Non-Melanoma, Casting
Time Frame: Start of study to end of study, up to 3 years
Determine the relationship between UV camera score, skin patch, sun exposure history, and phenotypic evaluation in non-melanoma patients using a silicone casts
Genetics Correlations
Time Frame: Start of study to end of study, up to 3 years
Determine whether UV exposure and camera scores correlates with UV signature (somatic) mutations and other tumor-related mutations in clinically benign nevi and primary melanomas using saliva samples, benign nevi, and primary melanomas. Next Generation Sequencing (NGS) will be used to obtain the genetic information from all samples.
Visual Appearance Relationships: Melanoma, Photography
Time Frame: Start of study to end of study, up to 3 years
Determine the relationship between UV camera score, skin patch, sun exposure history, and phenotypic evaluation in melanoma patients using a UV photography
Visual Appearance Relationships: Non-Melanoma, Photography
Time Frame: Start of study to end of study, up to 3 years
Determine the relationship between UV camera score, skin patch, sun exposure history, and phenotypic evaluation in non-melanoma patients using a UV photography
Visual Appearance Relationships: Non-Melanoma , Questionnaire
Time Frame: Start of study to end of study, up to 3 years
Determine the relationship between UV camera score, skin patch, sun exposure history, and phenotypic evaluation in non-melanoma patients using a sun exposure questionnaire
Visual Appearance Relationships: Melanoma, Casting
Time Frame: Start of study to end of study, up to 3 years
Determine the relationship between UV camera score, skin patch, sun exposure history, and phenotypic evaluation in melanoma patients using a silicone casts
Visual Appearance Relationships: Melanoma, Questionnaire
Time Frame: Start of study to end of study, up to 3 years
Determine the relationship between UV camera score, skin patch, sun exposure history, and phenotypic evaluation in melanoma patients using a sun exposure questionnaire
Visual Appearance Relationships: Melanoma, SCINEXA
Time Frame: Start of study to end of study, up to 3 years
Determine the relationship between UV camera score, skin patch, sun exposure history, and phenotypic evaluation in melanoma patients using a SCINEXA exam.
Secondary Outcomes
- Primary Melanomas, UV Camera(Start of study to end of study, up to 3 years)
- Benign Nevi, Mutations(Start of study to end of study, up to 3 years)
- Primary Melanomas, DNA(Start of study to end of study, up to 3 years)
- Benign Nevi, DNA(Start of study to end of study, up to 3 years)
- Benign Nevi, UV Camera(Start of study to end of study, up to 3 years)
- Self Reporting Behaviors(Start of study to end of study, up to 3 years)
- Primary Melanomas, Mutations(Start of study to end of study, up to 3 years)
- Primary Melanomas, Exposure(Start of study to end of study, up to 3 years)
- Behavioral Intervention and Immediate Follow Up(After wearing dosimetry for 3 weeks)
- Benign Nevi, Exposure(Start of study to end of study, up to 3 years)