Comparison of cellular response in dental procedures using synthetic bone grafts compared with bovine grafts in dentistry

Not Applicable

Recruiting

• Conditions: Disorder of the gingiva and alveolar ridge without teeth without other specification. Lifting the Floor of the Maxillary Sinus. Dental extraction; k06.9

• Registration Number: RBR-8cbp4xh
• Lead Sponsor: niversidade Federal do Mato Grosso do Sul

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-05-07
• Last Update Posted: 29 May 2023
• Study Completion: 2027-03-01

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Healthy patients; Be over 18 years old; Enjoy good systemic health; Enjoy good oral health; Have at least 2 teeth that require extraction; Need for surgery to lift bilateral sinus; Anterior teeth that require extraction and that have large alveoli to facilitate the collection of bone tissue without compromising the installation of the dental implant that will be performed concurrently; Posterior teeth that require extraction will only be used if the upper posterior teeth have a broad palatal root socket that will facilitate the collection of bone tissue without compromising the installation of the dental implant performed concurrently with obtaining the material; the lower posterior teeth have a wide distal root socket that will facilitate the collection of bone tissue without compromising the installation of the dental implant carried out concurrently to obtain the material; Maxillary sinuses free from infectious processes and / or pathologies that will harm the research result; Maxillary sinuses without major resorption and that anatomically allow the grafting of biomaterials

Exclusion Criteria

Volunteers under 18 years old; with poor oral hygiene; Sinus pathologies; Have teeth with acute infection and suppuration at the site to be filled with biomaterial; Teeth with large septa that will influence sample collection, altering histomorphological and immunohistochemical data due to the presence of native bone; Maxillary sinuses with inflammatory, infectious or tumor pathologies; Maxillary sinuses with great bone resorption that hinder the nutrition of the grafted biomaterials; Present a picture of any other oral infection; Have undergone radiotherapy of the head and neck; Be a user of bisphosphonates; Present decompensated diabetes mellitus; Pregnant woman; Present a smoking habit with a potential capacity to compromise dental implantation (greater than 10 cigarettes per day); Being of indigenous ethnicity

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assess whether there will be recovery of bone tissue lost after tooth extraction in the studied groups, through histomorphometric evaluation and imaging tests.

Secondary Outcome Measures

Name	Time	Method
Perform the quantification of bone formed in sites filled with synthetic biomaterial than using bovine biomaterial or a similarity in the groups