Improving cognitive functioning in Parkinson*s disease with transcranial Direct Current Stimulation (PD-tDCS)

Phase 2

Completed

• Conditions: cognitieve stoornissen; Parkinson's Disease-related mild cognitive impairment (PD-MCI); 10028037

• Registration Number: NL-OMON42486
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

1) Clinical diagnosis of PD according to the UK PD Brain Bank criteria60
2) PD-related mild cognitive impairment (PD-MCI)
3) If applicable, stable maintenance of their medication, including dopaminergic treatment, for at least 30 days prior to enrollment and throughout the study.;For the collection on data on instrumental activities of daily living
4) Presence of an informal informant
5) Ability of the informant to complete the questionnaire.

Exclusion Criteria

1) Insufficient mastery of the Dutch language
2) Inability to understand test instructions in Dutch language
3) Any contra indications to tDCS like metallic implants (pacemaker etc.)
4) History of seizures
5) Substance abuse
6) Dementia
7) Major head trauma
8) Bipolar or psychiatric disorder
9) Signs of depression (Hospital Anxiety and Depression Scale, sub score D >7)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Efficacy of atDCS in the improvement of executive functioning in PD-MCI.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Network connectivity as a predictor and monitor of treatment response<br /><br>Instrumental activities of daily living<br /><br>Motor symptoms<br /><br>Pain perception<br /><br>Health-related quality of life<br /><br>Mood</p><br>