L-carnitine Corrects Ammonia Metabolism in Hepatectomized Patients
- Registration Number
- NCT03021876
- Lead Sponsor
- Kochi University
- Brief Summary
L-carnitine is synthesized from lysine and methionine. Postmortem concentrations of carnitine in liver, muscle, heart, kidney, and brain averaged only one-fourth to one-third those in corresponding tissues of eight normally nourished non-hepatic patients who died after an acute illness of a 1-3-day duration. In the recent years, it has been reported that sirtuin 3 (SIRT3) is protective against acute kidney injury (AKI) and suggest that enhancing SIRT3 to improve mitochondrial dynamics has potential as a strategy for improving outcomes of renal injury. In the current study, it is the first clinical interventional research whether L-carnitine corrects ammonia metabolism associated with liver injury in hepatectomized patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
- patients were those surgically treated for hepato-biliary diseases
- Patient exclusion criteria included a body weight loss greater than 10% during the six months prior to surgery, the presence of distant metastases, or seriously impaired function of vital organs due to respiratory, renal or heart disease.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description ordinary group usual intake usual intake prior to liver surgery carnitine group L-carnitine treatment with oral L-carnitine, 1500 mg/body per day for 2 weeks prior to liver surgery
- Primary Outcome Measures
Name Time Method postoperative ammonia levels 3 points; preoperative baseline, postoperative day 1, and day3 change from preoperative baseline at postoperative day 1 and day3
- Secondary Outcome Measures
Name Time Method length of hospitalization after liver resection up to 24 weeks postoperative days
Trial Locations
- Locations (1)
Kochi Health Sciences Center
🇯🇵Kochi, Japan