Cannabis Abstinence and Neurocognitive Assessment in Adolescence

Recruiting

• Conditions: Cannabis Dependence; Harmful Use; Cognitive Assessment

• Registration Number: NCT07160153
• Lead Sponsor: University Hospital Pilsen

Brief Summary

Cannabis Abstinence and Neurocognitive Assessment in Adolescence

Detailed Description

Evaluate the development of cognitive functions following attainment of abstinence in a group of adolescents with cannabis dependence or harmful cannabis use. Abstinence is confirmed by toxicological testing.

Study Timeline

• Study Start: 2024-12-03
• Status Verified: 2025-08
• Study First Submitted: 2025-08-27
• Study First Submitted QC: 2025-08-27
• Last Update Submitted: 2025-08-27
• Study First Posted: 2025-09-08
• Last Update Posted: 2025-09-08
• Primary Completion: 2028-12-31
• Study Completion: 2029-08-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• Adolescents aged 15-18 years with a diagnosis of cannabis dependence or harmful cannabis use.

Exclusion Criteria

• psychiatric comorbidity - Dual diagnosis, including psychotic disorders, mood disorders, severe organic brain damage, or autism spectrum disorder, with the exception of compensated and stabilized anxiety disorder. Psychopharmacological treatment is permitted, except for antipsychotics prescribed for psychosis.
• somatic comorbidity - Severe endocrine disorders such as diabetes mellitus, thyroid dysfunction, or severe cardiovascular disease.
• Violation of abstinence between the first and second neuropsychological assessments, as well as severe decompensation of mental state requiring modification of established psychopharmacological treatment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in performance TMT-B	8 weeks	Change in performance on the Trail Making Test - Part B (TMT-B) \[Time Frame: after 8 weeks of abstinence from cannabis\]

Secondary Outcome Measures

Name	Time	Method
Change in performance on AVLT	8 weeks	Change in performance on the Auditory Verbal Learning Test (AVLT) \[Time Frame: after 8 weeks of abstinence\]
Change in performance on the Stroop Test	8 weeks	Change in performance on the Stroop Test \[Time Frame: after 8 weeks of abstinence\]
Change in performance on the Tower of London	8 weeks	Change in performance on the Tower of London (Shallice version) \[Time Frame: after 8 weeks of abstinence\]
Change in performance on CPT-IP	8 weeks	Change in performance on the Continuous Performance Test - Identical Pairs (CPT-IP) \[Time Frame: after 8 weeks of abstinence\]

Trial Locations

Locations (1)

University Hospital Pilsen; 🇨🇿 Pilsen, Czechia, Czechia