Preventive effect of proton-pump inhibitor for upper gastrointestinal injury induced by low-dose aspirin in patients with ischemic stroke
Not Applicable
- Conditions
- Patients who takes low-dose aspirin (less than 324 mg) daily for ischemic stroke that had developed 1 month or more before entry.
- Registration Number
- JPRN-UMIN000002051
- Lead Sponsor
- Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 500
Inclusion Criteria
Not provided
Exclusion Criteria
1)Subjects in whom ulcers (3 mm or more in diameter) at the initial endoscopy. 2)Subjects who has been taking PPI at entry. 3)Subjects who has taken some NSAIDs other than aspirin within 1 month. 4)Subjects with a history of allergy for aspirin, rabeprazole or famotitine. 5)Subjects with severe liver damage, renal dysfunction, or congestive heart failure. 6)Subjects with malignancy. 7)Others.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) Symptoms 2) Quality of life 3) Erosion 4) Gastrroduodenal ulcer 5) Gastrointestinal bleeding
- Secondary Outcome Measures
Name Time Method