Research on the effect of a proton pump inhibitor on the oral and intestinal microbiota and salivary protein and metabolites.
Not Applicable
- Conditions
- healthy volunteer
- Registration Number
- JPRN-UMIN000025331
- Lead Sponsor
- Shimane university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
Not provided
Exclusion Criteria
1) daily usage of steroids, immunosuppresive and anticancer drugs 2) 20 or fewer teeth 3) using antibiotics during use or within 1 month 4) During pregnancy, lactating, a woman who may be pregnant 5) history of allergy to esomeprazole 6) A case of a history of resection of the gastrointestinal tract except for appendectomy 7) the research director judged inappropriate as the subject of this research
Study & Design
- Study Type
- Others,meta-analysis etc
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ten adult healthy volunteers with no medications donated the fecal, saliva and periodontal pocket fluid samples before and after administration of esomeprazole 20mg once daily for 4 weeks. We then investigate the effect of PPIs on the bacterial communities using 16S rRNA gene sequencing method.
- Secondary Outcome Measures
Name Time Method