Assessment of response to antacids in children with Eosinophilic Esophagitis
- Conditions
- Eosinophilic Esophagitis
- Registration Number
- RBR-2ntbth9
- Lead Sponsor
- Hospital Santa Casa de Misericórdia de Porto Alegre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Children and Adolescents aged 1month to 18 years who were referred to the pediatric endoscopy unit were included. Patients were included when they met the diagnosis criteria for Eosinophilic esophagitis (presenting at least one symptom of esophageal dysfunction; esophageal biopsy with more than 15 eosinophil per high power field) and absence of gastric and duodenal eosinophilia. 4 to 6 biopsies were randomly obtained from the
distal and middle esophagus. Biopsies specimens were also obtained from the antrum and duodenum to exclude gastritis and eosinophilic gastroenteritis
Children were excluded if they had received prior and recent (up to 1 month before the endoscopy) treatment with proton pump inhibitor; corticosteroids or elimination diet; or if they presented duodenal or gastric eosinophilia or viral, fungal or caustic esophagitis
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method It is expected to find a therapeutic response in pediatric patients with eosinophilic esophagitis who received proton pump inhibitor medication
- Secondary Outcome Measures
Name Time Method It is expected to find demographic associations in pediatric patients with eosinophilic esophagitis that received proton pump inhibitors medication. Its is expected to find clinical, endoscopic and histological associations in pediatric patients with eosinophilic esophagitis who received proton pump inhibitor medication