NL-OMON52172招募中4 期
The glutamate/GABA balance as novel therapeutic target for psychotic and cognitive symptoms in 22q11.2 deletion syndrome - Riluzole in 22q11.2 DS
Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 46 人开始时间: 待定最近更新:
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 46
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 16 至 64（—）
入选标准
- •Confirmed diagnosis of 22q11.2 deletion syndrome established by FISH,
- •microarray or MLPA
- •16 year or older of age and mentally competent (determined by an experienced
- •physician) to
- •decide about participation and give informed consent.
- •16 years, incompetent to provide written informed consent. In these cases
- •consent will be
- •obtained from the legal representative of the subject.
- •Presence of psychotic and/or cognitive symptoms (defined as a score of >=4,
- •moderately ill, on the
- •Clinical Global Impression-Schizophrenia Scale (CGI-SCH)).
排除标准
- •Other chromosomal abnormalities.
- •Current substance abuse / dependence.
- •Use of psychotropic medication and / or first-generation antipsychotics or
- •clozapine, with the
- •exception of second-generation antipsychotics.
- •Contraindications for MRI.
- •Pre-existing liver function disorders and / or ALAT/ASAT > 3x ULN.
- •Contraindications for riluzole.
- •Pregnancy, or trying to get pregnant and breastfeeding.
- •In case of mentally incompetent patients, resistance to participation will be
- •an additional exclusion
研究者
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