NL-OMON28681尚未招募不适用
The glutamate/GABA balance as novel therapeutic target for psychotic and cognitive symptoms in 22q11.2 deletion syndrome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- MUMC
- 入组人数
- 45
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Confirmed diagnosis of 22q11.2 deletion syndrome established by FISH, microarray or MLPA analysis.
- •16 year or older of age and mentally competent (determined by an experienced physician) to decide about participation and give informed consent.
- •Presence of psychotic and/or cognitive symptoms (defined as a score of =4, moderately ill, on the Clinical Global Impression-Schizophrenia Scale (CGI-SCH)).
排除标准
- •Other chromosomal abnormalities.
- •Current substance abuse / dependence.
- •Use of psychotropic medication and / or first-generation antipsychotics or clozapine.
- •Contraindications for MRI.
- •Contraindications for riluzole.
- •Pre-existing liver function disorders and / or ALAT/ASAT > 3x ULN.
- •Pregnancy or trying to get pregnant and breastfeeding.
研究者
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