The effect of transfusion on cerebral oxygenation in traumatic brain injury

Completed

• Conditions: Traumatic brain injury; Injury, Occupational Diseases, Poisoning; Brain

• Registration Number: ISRCTN89085577
• Lead Sponsor: Cambridge University Hospitals NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-10-06
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Greater than 16 years of age
2. Severe traumatic brain injury (i.e. traumatic brain injury resulting in a resuscitated Glasgow coma score of less than or equal to 8, resulting in intracranial hypertension (greater than 20 mmHg for greater than 10 minutes), or requiring neurosurgical intervention
3. Informed assent from the next of kin

Exclusion Criteria

1. Active haemorrhage
2. Active coronary ischaemia as judged by dynamic electrocardiogram (ECG) changes or positive troponin levels not due to myocardial contusion
3. Inability to place cerebral oxygenation monitors
4. Failure to fall below allocated transfusion threshold during intracranial pressure (ICP) monitoring

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Brain tissue oxygen partial pressure.

Secondary Outcome Measures

Name	Time	Method
1. Jugular venous saturation<br>2. Lactate/pyruvate ratio<br>3. Neurological outcome<br>4. Cerebral haemodynamics