The effect of clarithromycin and doxycycline treatment on chronic rhinosinusitis with polyps after functional endoscopic sinus surgery

Not Applicable

Conditions: Chronic Rhinosinusitis - Nasal Polyps.
Chronic Sinusitis – Nasal polyp
J32-J33

Registration Number: IRCT20221224056910N1

Lead Sponsor: Rasht University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 192

Inclusion Criteria

Consent to participate in the study
Age 18 - 65 years
Disease diagnosis based on clinical symptoms and computerized tomography scan (CT scan) by an Otorhinolaryngology surgeon
Presence of sinus polyps with no clinical response to antibiotic treatments
Patients with a Lund Mackay score of 20 or above
Normal coagulation tests including prothrombin time (PT) , partial thromboplastin time (PTT), international normalized ratio (INR)
History of endoscopic nasal surgery before the study

Exclusion Criteria

History of systemic diseases involving the nose and sinuses such as Wegener's disease, sarcoidosis, cicatricial pemphigoid, acquired immunodeficiency syndrome (AIDS) , T-cell lymphoma, primary ciliary dyskinesia, cystic fibrosis, tumors of the nose and sinuses
Fungal sinusitis
History of allergy to macrolides or tetracyclines
Pregnancy and breastfeeding in women
History of coagulation disease (such as hemophilia) or the use of anticoagulants such as heparin
Severe systemic diseases such as uncontrolled diabetes or severe congestive heart failure
Mucocele
Surgery complications
Taking medications with drug interactions with the antibiotics using in this study

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Recurrence of disease. Timepoint: First, third, and sixth months follow up. Method of measurement: Based on physical examination and endoscopic findings.;Sinonasal outcome. Timepoint: First, third, and sixth months follow up. Method of measurement: Based on sino-nasal outcome test 22 score (SNOT-22 score).

Secondary Outcome Measures

Name	Time	Method
Endoscopic condition. Timepoint: First, third,and sixth months follow up. Method of measurement: Lund-Kennedy scale.;Drugs adverse effects. Timepoint: First, third, sixth months follow up. Method of measurement: Clinical history and physical examination.