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Initiative for Patient Outcomes in Dialysis - Peritoneal Dialysis (PD) (IPOD-PD Study)

Completed
Conditions
Chronic Renal Failure
Registration Number
NCT01285726
Lead Sponsor
Fresenius Medical Care Deutschland GmbH
Brief Summary

The aim of the study is to asses the hydration status of incident peritoneal dialysis (PD) patients and its evolution over a period of four years, independent of the PD treatment modality (APD or CAPD) and the PD solution type.

Detailed Description

Achieving optimal fluid balance remains a major clinical challenge in peritoneal dialysis (PD) patients. With the recent development of a new bioimpedance spectroscopy (BIS) device, the BCM-Body Composition Monitor (BCM), it is now possible to quantify deviations of hydration status and to define target weight directly.

It has been observed that more than 50% of the PD patients are overhydrated, as compared to the healthy population. This overhydration seems to be associated with modifiable practice-related factors, such as correct PD prescription according to membrane transport status, and dietary fluid intake.

The aim of this study is to assess the hydration status of incident PD patients, and diagnose the underlying reasons for incorrect fluid status. In addition, changes in fluid status, residual renal function and nutritional status, over a follow-up period of up to four years will be registered.

The investigators assume that the use of the BCM-Body Composition Monitor (BCM) provides quantitative measurement of hydration status and thereby supports physicians in identifying patients who are not euvolaemic. Hence, the BCM allows an improved management of underlying causes of non-euvolaemic hydration state and appropriate monitoring of fluid status.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
1092
Inclusion Criteria
  • Incident patients directly before start of peritoneal dialysis
  • Patients in whom routine measurement of body composition monitoring is performed
Exclusion Criteria
  • Patients treated with HD before start of PD
  • Patients in whom body composition monitoring cannot be performed

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Hydration statusEvery three months over a period of four years

Assessed via body composition measurements (Overhydration, total body water (TBW), extracellular water (ECW), intracellular water (ICW)) (Overhydration, total body water (TBW), extracellular water (ECW), intracellular water (ICW))

Secondary Outcome Measures
NameTimeMethod
Changes in PD prescriptionFour years
Residual renal functionEvery three months over a period of four years
Peritoneal transport statusEvery three months over a period of four years
Time to change to haemodialysisFour years

Trial Locations

Locations (134)

Třebíč Hospital

🇨🇿

Trebic, Czech Republic

North Estonian Regional Hospital

🇪🇪

Tallinn, Estonia

University Hospital FN Brno Bohunice

🇨🇿

Brno, Czech Republic

FN Hradec Kralove

🇨🇿

Hradec Kralove, Czech Republic

VFN Strahov

🇨🇿

Prague, Czech Republic

Tartu University Hospital

🇪🇪

Tartu, Estonia

Keski-Suomen keskussairaala, Jyväskylä

🇫🇮

Jyväskylä, Finland

Nordlandssykehuset Bodø

🇳🇴

Bodø, Norway

Sykehuset Levanger

🇳🇴

Levanger, Norway

CHP Hospital Santo Antonio

🇵🇹

Porto, Portugal

Cenesuca (FME Cumana)

🇻🇪

Cumana, Venezuela

FME Zulia

🇻🇪

Maracaibo, Venezuela

Luzern Kantonsspital

🇨🇭

Luzern, Switzerland

FMC El tigre Edo Anzoátegui

🇻🇪

El Tigre, Venezuela

FME Puerto de la Cruz

🇻🇪

Puerto La Cruz, Venezuela

UH Merkur

🇭🇷

Zagreb, Croatia

ASZ Aalst

🇧🇪

Aalst, Belgium

CDR Barra do Piraí

🇧🇷

Pirai, Brazil

KBC Mostar

🇧🇦

Mostar, Bosnia and Herzegovina

Klinikum Wels

🇦🇹

Wels, Austria

CHU Sart Tilman

🇧🇪

Liège, Belgium

Instituto Mineiro Nefrologia

🇧🇷

Belo Horizonte, Brazil

CHU de Bordeaux

🇫🇷

Bordeaux, France

Instituto de Nefrología

🇨🇺

La Habana, Cuba

Kymenlaakson keskussairaala, Kotka

🇫🇮

Kotka, Finland

Heilig-Hart Roeselare

🇧🇪

Roeselare, Belgium

Hôpital Civil de Strasbourg

🇫🇷

Strasbourg, France

CHU Albacete

🇪🇸

Albacete, Spain

General University Hospital of Ioannina

🇬🇷

Ioannina, Greece

UHC Osijek

🇭🇷

Osijek, Croatia

Ospedale San Bartolo

🇮🇹

Vicenza, Italy

NHIC Ilsan Hospital

🇰🇷

Goyang, Korea, Republic of

Nierenzentrum Heidelberg

🇩🇪

Heidelberg, Germany

Yeungnam University Hospital

🇰🇷

Daegu, Korea, Republic of

KfH Nierenzentrum Bottrop

🇩🇪

Bottrop, Germany

Fundació Puigvert

🇪🇸

Barcelona, Spain

UKC Tuzla

🇧🇦

Tuzla, Bosnia and Herzegovina

UH Split

🇭🇷

Split, Croatia

Faculty Hospital Plzen

🇨🇿

Pilsen, Czech Republic

General Hospital of Ioannina

🇬🇷

Ioannina, Greece

UO Nefrologia Policlinico BARI

🇮🇹

Bari, Italy

Azienda Ospedaliera Brotzu

🇮🇹

Cagliari, Italy

C.H. Dunkerque

🇫🇷

Dunkerque, France

ECHO Confluent

🇫🇷

Rezé, France

Hospital Carlos Haya

🇪🇸

Malaga, Spain

CETENE

🇧🇷

Sao Paolo, Brazil

Nephrologische Praxis Wiesbaden

🇩🇪

Wiesbaden, Germany

Western Galilee Hospital

🇮🇱

Nahariyya, Israel

IKEM

🇨🇿

Prague, Czech Republic

Hôpital Bichat - Claude Bernard

🇫🇷

Paris, France

Hospital Clínico de Valencia

🇪🇸

Valencia, Spain

General University Hospital of Alexandroupolis

🇬🇷

Alexandroupolis, Greece

General University Hospital of Thessaloniki "AHEPA"

🇬🇷

Thessaloniki, Greece

Skånes Universitetssjukhus Malmo

🇸🇪

Malmo, Sweden

Karolinska Univers. Hospital

🇸🇪

Stockholm, Sweden

AUB Quimper / Centre Hospitalier Laennec

🇫🇷

Quimper, France

Hospital Universitario A Coruñ

🇪🇸

A Coruña, Spain

Hospital De Torrecardenas

🇪🇸

Almeria, Spain

Hospital General de Castellón

🇪🇸

Castellón, Spain

MMM - Chennai

🇮🇳

Chennai, India

General Hospital of Athens G. Gennimatas

🇬🇷

Athens, Greece

Ospedale Civico Palermo

🇮🇹

Palermo, Italy

Akdeniz Universitesi

🇹🇷

Antalya, Turkey

Hospital Univ. de Puerto Real

🇪🇸

Puerto Real, Spain

Hospital Josep Trueta

🇪🇸

Girona, Spain

HGU Gregorio Marañon

🇪🇸

Madrid, Spain

Centre Hospitalier René Dubos

🇫🇷

Pontoise, France

Hospital de Mollet

🇪🇸

Mollet del Valles, Spain

Nieren und Hochdruckzentrum Kiel

🇩🇪

Kiel, Germany

Hospital Txagorritxu

🇪🇸

Vitoria, Spain

Fundación Hospital Manacor

🇪🇸

Manacor, Spain

Hospital Santa Cruz

🇵🇹

Carnaxide, Portugal

University Hospital Maastricht

🇳🇱

Maastricht, Netherlands

Mälarsjukhuset Eskilstuna

🇸🇪

Eskilstuna, Sweden

Sunderby Sjukhus

🇸🇪

Luleå, Sweden

Hospital Univ. Puerta del Mar

🇪🇸

Cádiz, Spain

Hospital Clinico San Carlos

🇪🇸

Madrid, Spain

Hospital Univ. Ramón y Cajal

🇪🇸

Madrid, Spain

CAULE

🇪🇸

León, Spain

Western Infirmary Glasgow

🇬🇧

Glasgow, United Kingdom

Royal London Hospital

🇬🇧

London, United Kingdom

FME Maturin

🇻🇪

Maturin, Venezuela

Hospital Universitario Puerta

🇪🇸

Madrid, Spain

Hosp. Univ. Fundacion Alcorcon

🇪🇸

Alcorcon, Spain

Hospital de Galdakano

🇪🇸

Bilbao, Spain

Hospital Lucus Augusti

🇪🇸

Lugo, Spain

Hospital Clínic de Barcelona

🇪🇸

Barcelona, Spain

FME Charallave

🇻🇪

Charallave, Venezuela

Sahlgrenska PD-mottagningen

🇸🇪

Göteborg, Sweden

Hallands Hospital Halmstad

🇸🇪

Halmstad, Sweden

Hospital general de Vic

🇪🇸

Vic, Spain

Herlev Hospital

🇩🇰

Herlev, Denmark

Hospital Universitario Central

🇪🇸

Oviedo, Spain

Hospital Virgen de la Macarena

🇪🇸

Sevilla, Spain

Hospital Severo Ochoa

🇪🇸

Madrid, Spain

Hospital Rio Hortega

🇪🇸

Valladolid, Spain

CHU Xeral Cies Vigo

🇪🇸

Vigo, Spain

Ghent University Hospital

🇧🇪

Gent, Belgium

Hillerød Hospital

🇩🇰

Hillerød, Denmark

Roskilde Hospital

🇩🇰

Roskilde, Denmark

Klinikum Braunschweig

🇩🇪

Braunschweig, Germany

Robert Bosch Krankenhaus

🇩🇪

Stuttgart, Germany

Nephrologisches Zentrum Velbert Innere Medizin und Nephrologie

🇩🇪

Velbert, Germany

P. Stradins hospital

🇱🇻

Riga, Latvia

Seoul National University Hospitall

🇰🇷

Seoul, Korea, Republic of

Konkuk University Medical Center

🇰🇷

Seoul, Korea, Republic of

Med Alfa Ltda

🇱🇻

Riga, Latvia

Severance Hospital

🇰🇷

Seoul, Korea, Republic of

Kaunas clinics

🇱🇹

Kaunas, Lithuania

Complejo Hospitalario de Jaén

🇪🇸

Jaén, Spain

CHUS

🇪🇸

Santiago de Compostela, Spain

HUM Valdecilla

🇪🇸

Santander, Spain

Danderyds Hospital

🇸🇪

Stockholm, Sweden

Kungsholmsdialysen

🇸🇪

Stockholm, Sweden

Fundación Jiménez Díaz

🇪🇸

Madrid, Spain

Hospital de Basurto

🇪🇸

Bilbao, Spain

Hospital San Pedro

🇪🇸

Logroño, Spain

St. Olavs Hospital

🇳🇴

Sluppen, Norway

Oulu University Hospital

🇫🇮

Oys, Finland

Satakunnan keskussairaala, Pori

🇫🇮

Pori, Finland

Klaipeda Republic Hospital

🇱🇹

Klaipeda, Lithuania

Sykehuset i Møre og Romsdal HF

🇳🇴

Aalesund, Norway

Helsinki University Hospital

🇫🇮

Helsinki, Finland

FME Caracas

🇻🇪

Caracas, Venezuela

FME Maracay

🇻🇪

Turmero, Venezuela

DS Most

🇨🇿

Most, Czech Republic

West Talinn Central Hospital

🇪🇪

Tallinn, Estonia

Central Hospital in Joensuu

🇫🇮

Joensuu, Finland

Vilnius Univ. Antakalnio Hospital

🇱🇹

Vilnius, Lithuania

Nefrologico Valencia sur

🇻🇪

Valencia, Venezuela

Tampere University Hospital

🇫🇮

Tampere, Finland

Instituto Docente de Urologia

🇻🇪

Valencia, Venezuela

U.Z. Leuven

🇧🇪

Leuven, Belgium

ASZ Geraardsbergen

🇧🇪

Geraardsbergen, Belgium

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