A Comparison of Efficacy of Preoperative Nebulized Magnesium Sulphate (50 Percent) Versus Plain Lignocaine (2 Percent) For the Prevention of Postoperative Sore Throat in Patients Requiring Endotracheal Intubation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- To compare the incidence of Postoperative Sore Throat (POST) among patients receiving nebulized magnesium sulphate (50%) and those receiving nebulized plain lignocaine (2%) requiring endotracheal intubation.
研究概览
简要总结
General anaesthesia plays a crucial role in the field of anaesthesia, with endotracheal intubation being a vital measure to safeguard the airway. Postoperative sore throat, hoarseness of voice, and cough often follow endotracheal intubation.
Postoperative sore throat (POST) stands out as a frequent consequence of endotracheal intubation lasting for about 12-24 hrs after surgery, with reported prevalence ranging from 18 to 65%.
Various pharmacological and non-pharmacological methods have been employed to manage postoperative sore throat following general anaesthesia. Pharmacological methods like Nebulization with beclomethasone and Fluticasone, gargling with azulene sulfonate, aspirin, ketamine, lignocaine and magnesium, benzydamine, green tea, hydrochloride and licorice and local spray of benzydamine hydrochloride, lignocaine with varying degrees of effectiveness.
Few studies have been published on efficacy of preoperative nebulised ketamine, magnesium sulphate, lignocaine and normal saline on postoperative sore throat, but very few comparing the efficacy of Magnesium sulphate and Lignocaine on postoperative sore throat.
The data being collected from this study will be used to establish a standardised preoperative protocol which could be applicable in our institute and other healthcare settings further being beneficial to the patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
入选标准
- •ASA Grade I and II Mallampati Grade I and II Age :18-50 years Weight: 50-80 kg Both Male and Female Genders Patients undergoing surgery with duration ranging from 1-3 hrs under general anaesthesia with tracheal intubation.
排除标准
- •Patient refusal for Nebulization Patients undergoing Head and Neck Surgeries Patients with a history of preoperative sore throat or any respiratory disease Pregnant/Lactating females Patients allergic to the study drugs Patients with compromised renal function, cardiac diseases and neuromuscular disease.
- •Patients with NasoGastric tube or any nasal or throat packs or who require these intraoperatively.
- •Patients with anticipated difficult intubation.
- •Patients requiring laryngoscopy and intubation for over 30 seconds or necessitating more than one attempt for intubation.
- •Patients requiring the chronic use of steroids and/or the use of NSAIDS.
结局指标
主要结局
To compare the incidence of Postoperative Sore Throat (POST) among patients receiving nebulized magnesium sulphate (50%) and those receiving nebulized plain lignocaine (2%) requiring endotracheal intubation.
时间窗: The incidence and severity of At 0 h (on arrival to post-anesthesia care unit (PACU)), 2, 4, 6, 8, 12 and 24 h postoperatively
次要结局
- To observe the occurrence of any side effects Eg. Nausea/Vomiting, skin rash, dry mouth, hypotension, bradycardia and cough etc.
研究者
Aditya Suresh Balasubramanian
GMERS Medical College, Gandhinagar