The Effect of a Peat and Apple Extract on Muscle ATP and Exercise Performance

Not Applicable

Completed

• Conditions: Caffeine and Endurance Performance
• Interventions: Dietary Supplement: Placebo; Dietary Supplement: ElevATP supplement

• Registration Number: NCT05641454
• Lead Sponsor: University of Exeter

Brief Summary

A study to test the hypothesis that a combined peat and apple extract will increase blood and muscle ATP, which will increase cycling performance

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-17
• Study First Submitted: 2022-11-01
• Study First Submitted QC: 2022-11-30
• Study First Posted: 2022-12-07
• Primary Completion: 2023-02-15
• Study Completion: 2023-02-15
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-21
• Last Update Posted: 2023-03-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

• Age 18 - 40
• Healthy
• Recreationally active (i.e. Participants will be deemed as too trained if they are defined as participating in structured resistance exercise 3 or more times per week for >6 months or participating in structured endurance exercise for >6h per week for >6 months. Participants will be defined as too sedentary if they do not exceed the governments guidelines of 150 / 75 min per week of light / heavy exercise.)

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Exclusion Criteria

• Allergy to Lidocaine
• Any diagnosed metabolic health condition
• Pregnant
• Non-habitual caffeine intake
• Smoker
• Diagnosed Cardiovascular disease
• Beta-Blockers
• Recent history of musculoskeletal injury

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Maltodextrin placebo	Placebo	-
ElevATP supplement	ElevATP supplement	-

Primary Outcome Measures

Name	Time	Method
Muscle ATP concentration	4 hours	Concentration of ATP in skeletal muscle tissue (mmol/kg dry weight)

Secondary Outcome Measures

Name	Time	Method
Muscle creatine concentration	4 hours (mmol/kg dry weight)	Concentration of muscle metabolites
Blood ATP concentration	4 hours	Concentration of ATP in blood (mmol/L)
Muscle ADP concentration	4 hours (mmol/kg dry weight)	Concentration of muscle metabolites
Total work performed during exercise	2 hours	Work performed during glycogen depleting exercise on a cycle ergometer (J)
Substrate oxidation	1 hour	Substrate oxidation over 1 h steady state cycle (g/min)
Blood lactate concentration	4 hours	Concentration of lactate in blood (mmol/L)
Muscle ATP concentration	4 hours (mmol/kg dry weight)	Concentration of muscle metabolites
Muscle glycogen	4 hours	Muscle glycogen concentration in skeletal muscle tissue (mmol/kg dry weight)
Muscle phosphocreatine concentration	4 hours (mmol/kg dry weight)	Concentration of muscle metabolites
Blood glucose concentration	4 hours	Concentration of glucose in blood (mmol/L)

Trial Locations

Locations (1)

University of Exeter; 🇬🇧 Exeter, Devon, United Kingdom