An early diagnosis of asthma in young children by using non-invasive biomarkers of oxidative stress/airway inflammatio

Completed

• Conditions: asthma; 10024970

• Registration Number: NL-OMON31104
• Lead Sponsor: Academisch Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 250

Inclusion Criteria

Two groups are included:
- Children aged 2-3 years, with recurrent respiratory symptoms suggestive of
astma;
- Children aged 2-3 years, with no or minor respiratory symptoms

Exclusion Criteria

mental retardation, cardiac abnormalities, congenital anomalies, other respiratory diseases, chronic inflammatory diseases (e.g. Morbus Crohn, rheumatoid arthritis), inability to perform the exhaled air and lungfunction procedures properly

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters are:<br /><br>- Biomarkers in exhaled breath condensate: IL-13, IFN-gamma, MIF, en sICAM<br /><br>- Biomarkers in exhaled breath : FeNO en VOC*s </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secundary parameters voor deze studie zijn:<br /><br>- In serum:<br /><br>Treg cells, proteins measured by proteomics, antioxidant/ oxidant markers<br /><br>(glutathione en superoxide dismutase), genexpression of IL-4, IL-13 en TNF<br /><br>alpha, polymorfism of ADAM 33, IL-4 en TNF alpha, RS virus, chlamydia<br /><br>pneumoniae, rotavirus, etc.<br /><br>-feces:<br /><br>bacteria/virusus zoals rotavirus, RS virus, pneumococcen, chlamydia</p><br>