A clinical trial to study the effects of two modalities of intravenous furosemide injection, continuous infusion and intermittent injections, in the management of edema (swelling) in children with nephrotic syndrome
Phase 3
Completed
- Registration Number
- CTRI/2009/091/000059
- Lead Sponsor
- il
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 26
Inclusion Criteria
Children diagnosed as nephrotic syndrome in the age group of 1 to 14 years, admitted for edema control were enrolled in the study if they had previously failed to respond to oral furosemide treatment in a dose of 2mg/kg/day
Exclusion Criteria
Hemodynamic instability
Serious infections (like meningitis, peritonitis etc.)
Congestive cardiac failure
Diarrhea, vomiting, hypovolemia
Dyselectrolytemia
Schwartz GFR (<40ml/min/1.73m2 calculated by formula)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in total urinary outputTimepoint: During the intervention
- Secondary Outcome Measures
Name Time Method Percentage weight loss ,Change in Osmolal clearance, Change in free water clearance,Total urinary sodium and potassium,Urinary sodium and potassium ,Fractional excretion of sodium ,Serum sodium and potassium ,Complications of treatment [Delete] <br><br><br><br><br><br>Timepoint: During the intervention