NCT00978640UnknownNot Applicable
Sirtuin Mediated Effects of 36 h Fast and 1 h Exercise
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- University of Aarhus
- Enrollment
- 8
- Locations
- 1
- Primary Endpoint
- Sirt1 activity
Study Overview
Brief Summary
Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).
Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.
In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •healthy men
- •Body mass index (BMI) 20-26
- •age 18-45 years
Exclusion Criteria
- •any kind of disease
- •any use of medicine
Arms & Interventions
fasting and exercise
Experimental
36 h fast and 1 h ergometer cycling 50% VO2max
Intervention: fast and exercise (Other)
exercise
Experimental
1 h ergometer cycling 50% VO2max
Intervention: exercise (Other)
Outcomes
Primary Outcomes
Sirt1 activity
Time Frame: 60 min
Secondary Outcomes
- secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.(4 h)
Investigators
Study Sites (1)
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