Study of Nutritional Status in Subacute Stroke Patients Under Rehabilitation Treatment

change in weight in kilograms

时间窗: baseline (T0), treatment (6 weeks)

it is a measure of body mass weight expressed in Kg

change in Bioimpedance analysis (BIA) measurements

时间窗: baseline (T0), treatment (6 weeks)

it is a non-invasive measurement of body fat, lean muscle mass and hydration

change in height in meters

时间窗: baseline (T0), treatment (6 weeks)

it is a measure of body mass height calculated in meters

change in food intake

时间窗: baseline (T0), treatment (6 weeks)

detection of food intake by means of food diary (measure of portion of dishes consumed; measure of water assumed). Food diary will include the monitoring of 3 days a week for 6 weeks.

change in concentration of total cholesterol serum levels in mg/dL

时间窗: baseline (T0), treatment (6 weeks)

serum measurements of total cholesterol in mg/dL

change in concentration of magnesium serum levels in mg/dL

时间窗: baseline (T0), treatment (6 weeks)

serum measurements of magnesium in mg/dL

change in Motricity Index (MI) scores

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

The MI aims to evaluate lower limb motor impairment after stroke, administrated on both sides. Items to assess the lower limbs are 3, scoring from 0 to 33 each: (1) ankle dorsiflexion with foot in a plantar flexed position (2) knee extension with the foot unsupported and the knee at 90° (3) hip flexion with the hip at 90° moving the knee as close as possible to the chin. (no movement: 0, palpable flicker but no movement: 9, movement but not against gravity :14, movement against gravity movement against gravity: 19, movement against resistance: 25, normal:33).

change in urine levels of indole and scatole

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

chromatographic with fluorimeter analysis of indole levels in urine

change in arm, waist and hips circumferences expressed in cm

时间窗: baseline (T0), treatment (6 weeks)

a measure of circumferences expressed in cm

change in concentration of blood levels of lymphocite expressed in count of cells or percentage

时间窗: baseline (T0), treatment (6 weeks)

blood measurements of total lymphocyte in count of cells or percentage

change in concentration of glucose serum levels in mg/dL

时间窗: baseline (T0), treatment (6 weeks)

serum measurements of glucose in mg/dL

change in Geriatric Nutritional Risk Index score

时间窗: baseline (T0), treatment (6 weeks)

is an index calculated from Lorentz' standardized weight and albumin

change in Mann Assessment of Swallowing Activity (MASA)

时间窗: baseline (T0), treatment (6 weeks)

The MASA consists of 24 items, and each measured score is converted into a weighted 5 or 10 points, which are then summed to a 200-point maximum score. The total scores are then used to define four categories of aspiration risk, as follows: 170-200, no abnormality; 149-169, mild; 141-148, moderate; ≤140, severe. The MASA score was evaluated by expert speech-language-hearing therapists within three days after admission.

change in Modified Ashworth Scale (MAS) scores

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

The MAS is a 6 point ordinal scale used for grading hypertonia in individuals with neurological diagnoses. A score of 0 on the scale indicates no increase in tone while a score of 4 indicates rigidity. Tone is scored by passively moving the individual's limb and assessing the amount of resistance to movement felt by the examiner.

change in Functional Ambulation Classification (FAC) scores

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

The Functional Ambulation Categories (FAC) is a 6-point functional walking test that evaluates ambulation ability, determining how much human support the patient requires when walking, regardless of whether or not they use a personal assistive device.

Changes in the Symbol Digit Modalities test at follow-up

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

The subject is given a sheet of paper at the top of which is printed the key (9 abstract symbols and 9 corresponding numbers). The key is available to the subject throughout the test. A sequence of 120 symbols, each printed in a square, is presented below the key. Empty squares are located below the squares containing the symbols. In the oral version, the examiner, on a copy of the test sheet, records in the empty squares the numbers the subject associates, orally, with the symbols. The subject has to make as many associations as possible within the 90-sec time limit. The score is the number of correct associations made by the subject.

change in concentration of blood levels of haemoglobin in g/dL

时间窗: baseline (T0), treatment (6 weeks)

blood measurements of haemoglobin (g/dL)

change in concentration of albumine serum levels in g/dL

时间窗: baseline (T0), treatment (6 weeks)

serum measurements of albumin in g/dL

change in concentration of triglycerides serum levels in mg/dL

时间窗: baseline (T0), treatment (6 weeks)

serum measurements of triglycerides in mg/dL

change in concentration of calcium serum levels in mg/dL

时间窗: baseline (T0), treatment (6 weeks)

serum measurements of calcium in mg/dL

change in hand grip strenght test score

时间窗: baseline (T0), treatment (6 weeks)

it is a test to measure the maximum isometric strenght of the hand and forearm muscles

change in Time Up & Go test (TUG) scores

时间窗: baseline (T0), treatment (6 weeks)

The Time Up And Go is a test used to assess mobility, balance, and walking in people with balance impairments. The subject must stand up from a chair (which should not be leant against a wall), walk a distance of 3 meters, turn around, walk back to the chair and sit down - all performed as quickly and as safely as possible. Time will be measured using a chronometer.

change in Fugl-Meyer Assessment of Motor Recovery after Stroke for Upper Extremity

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

The FMA-UL is a stroke-specific, performance-based impairment index. It is designed to assess motor functioning, sensation and joint functioning in patients with post-stroke hemiplegia. The upper limb portion of the FMA-UL ranges from 0 (hemiplegia) to 66 points (normal upper limb motor performance)

change in Numerical Rating Scale (NRS) scores

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

The Numeric Rating Scale (NRS) is the simplest and most commonly used numeric scale to rate the pain from 0 (no pain) to 10 (worst pain).

change in serum levels of systemic oxidative stress (dROMs)

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

dROMs test measures circulating hydroperoxides (UCarr)

change in Mini Nutritional Assessment scores

时间窗: baseline (T0), treatment (6 weeks)

questionnaire of evaluation of nutritional status- scores: 0-30- optimum of nutritional status (24-30) risk of malnutrition (17-23,5) malnutrition (\<17)

change in value of Body mass Index in kg/(m^2)

时间窗: baseline (T0), treatment (6 weeks)

it is a measure wich combine the height and weight values to report Body Mass Index (BMI) expressed in kg/m²; this parameter is valid for adult men and women

change in concentration of HDL cholesterol serum levels in mg/dL

时间窗: baseline (T0), treatment (6 weeks)

serum measurements of HDL cholesterol in mg/dL

change in score of Controlling Nutritional Status (CONUT)

时间窗: baseline (T0), treatment (6 weeks)

is a nutritional scoring tool that is calculated using serum albumin, total cholesterol level, total lymphocyte count

change in Functionl Oral Intake Scale (FOIS) score

时间窗: baseline (T0), treatment (6 weeks)

the Functional Oral Intake Scale (FOIS) assess a patient's food swallowing capability. This tool is designed to measure the effectiveness of a patient's oral intake.The FOIS has seven levels, each denoting a different type of oral intake ability. ITUBE DEPENDENT (levels 1-3) 1. No oral intake 2. Tube dependent with minimal/inconsistent oral intake 3. Tube supplements with consistent oral intake TOTAL ORAL INTAKE (levels 4-7) 4. Total oral intake of a single consistency 5. Total oral intake of multiple consistencies requiring special preparation 6. Total oral intake with no special preparation, but must avoid specific foods or liquid items 7. Total oral intake with no restrictions

change in Barthel index (BI) scores

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

The BI is designed to assess the ability of an individual with a neuromuscular or musculoskeletal disorder to care for him/herself. It ranges from 0 to 100, with a higher number meaning better performance in activities of daily living.

change in Neuropathic Pain Four Questions (DN4) scores

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

The DN4 used to evaluate presence of neuropathic pain, and consist of a brief interview of four questions answered yes/no: two on what the patient has conceived and two during the exam for the evaluation of hypoesthesia to the touch or sting and the evaluation of allodynia with the skimming of the skin. For each 'yes' a point is assigned. The total score is given by the sum of the individuals. The cut off for the presence of neuropathic pain is '4'.

change in three point pinch test

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

A pinch grip is a form of precision grip whereby a Pinch dynamometers is pinched in three ways.

Changes in the Montreal Cognitive Assessment (MoCA

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

The Montreal Cognitive Assessment (MoCA) was designed as a rapid screening instrument for mild cognitive dysfunction. It assesses different cognitive domains: attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation. Time to administer the MoCA is approximately 10 minutes. The maximum possible score is 30 points.

Changes in the kinematic analysis kinetic parameters: Force (N) towards 8 targets

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

Kinematic information recorded during the administration of the Evaluation Task provided by Motore, based on a center-out point-to-point reaching activity. The kinetics of the end-effector of the robot will be measured by the robot during reaching tasks performed by the patient against the device. The outcome will be the maximum values towards 8 targets.

change in gut microbiote composition

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

analysis of Next generation sequencing of 16S rDNA metabarcoding and shotgun metatrascriptomic of stool sample

change in serum levels of DAO

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

ELISA analysis of sieric diaminoxidase (DAO)

change in gut metabolomic composition of stool

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

analysis of volatile organic compounds (VOCs) and fecal zonuline in stool

change in urine levels of VOCs

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

analysis of volatile organic compounds (VOCs) in urine

change in 10 Meter Walk Test scores

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

This test will assess the patient's speed during gait. Patients will be asked to walk at their preferred maximum and safe speed. Patients will be positioned 1 meter before the start line and instructed to walk 10 meters, and pass the end line approximately 1 meter after. The distance before and after the course are meant to minimize the effect of acceleration and deceleration. Time will be measured using a stopwatch and recorded to the one hundred of a second (ex: 2.15 s). The test will be recorded 3 times, with adequate rests between them. The average of the 3 times should be recorded.

change in Six-Minute Walking Test (6MWT) scores

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

The 6MWT measures the distance a subject covers during an indoor gait on a flat, hard surface in 6 minutes, using assistive devices, as necessary. The test is a reliable and valid evaluation of functional exercise capacity and is used as a sub-maximal test of aerobic capacity and endurance. The minimal detectable change in distance for people with sub-acute stroke is 60.98 meters. The 6MWT is a patient self-paced walk test and assesses the level of functional capacity. Patients are allowed to stop and rest during the test. However, the timer does not stop. If the patient is unable to complete the test, the time is stopped at that moment. The missing time and the reason of the stop are recorded. This test will be administered while wearing a pulse oximeter to monitor heart rate and oxygen saturation, also integrated with Borg scale to assess dyspnea.

change in serum lipidic peroxidation (LP-Cholox)

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

LP-cholox test measure the lipidic peroxidation (micromol/L)

change in serum levels of zonuline

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

ELISA analysis of sieric zonuline

change in serum antioxydant capacity (BAP)

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

BAP test measures total antioxidant status in serum in micromol/L

change in sieric I-FABP

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

ELISA analysis of sieric Intestinal fatty acid binding protein (I-FABP)

change in Serum levels of LPS

时间窗: Baseline (T0), Treatment (6 weeks) (T1)

ELISA analysis of sieric Lipopolysaccharide (LPS)