Pathogenic role of virus-specific T-cells in corneas of patients with herpetic stromal keratitis (HSKPATH)

• Conditions: herpetic keratitis; 10021877; 10047438

• Registration Number: NL-OMON47972
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 65

Inclusion Criteria

Age >= 18 years.
Immunecompetent individual.
Positive HSV-1 infected
Documented ocular disease history for at least 1 year.
Indication for therapeutic corneal transplantation*

Exclusion Criteria

Individuals with documented HIV, HBV or HCV infection.
Individuals on immune therapy or did so in the past 3 months.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Characteristics of HSV-specific T-cells in diseased cornea tissue specimens of<br /><br>HSK and non-HSK patients.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>None</p><br>