De role of Cytomegalovirus-infection on T-cell dynamics after influenza vaccination in elderly

Completed

• Conditions: CMV ageing; immuunsysteem

• Registration Number: NL-OMON43423
• Lead Sponsor: RIVM

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2019-01-08
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

healthy elderly between 60 and 80 years old

Exclusion Criteria

- Immune related diseases (allergies, diabetes etc)
- Medicine use (heart, kidney failure etc)
- (A history of) cancer
- Drugs or extensive alcohol use
- Allergy for influenza vaccine
- Sea- or motion sickness

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The average production rate and lifetime of different T-cell populations after<br /><br>influenza vaccination in CMV-positive and CMV-negative elderly (phase 2). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Absolute numbers of different T-cell populations during the study period<br /><br>(both on base of phenotype markers as CMV-specific and influenza-specific T<br /><br>cells) (phase 2)<br /><br>- The presence/amount of CMV virus shedding in healthy individuals in saliva<br /><br>(phase 1)<br /><br>- The presence and level of CMV IgG antibodies (phase 1 and 2)<br /><br>- The presence/amount of CMV DNA and RNA in monocytes in CMV-positive<br /><br>individuals (phase 1)<br /><br>- Functionality of T cells against CMV (phase 1 and 2)</p><br>