Prevalence of Long-term Respiratory Complications of Severe SARS-CoV-2 Pneumonia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- CHU de Reims
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- medium-term respiratory complications
研究概览
简要总结
Studies performed after coronavirus epidemics (severe acute respiratory syndrome coronavirus, SARS-CoV and Middle East respiratory syndrome coronavirus, MERS-CoV) have shown a long-term impact on respiratory morbidity, musculoskeletal and psycho-social repercussions.
Patients with SARS-CoV pneumonia had fibrotic pulmonary sequelae at 45 days (lower DLCO in 27.3% of cases and radiological lesions in 21.5% of cases). In the MERS-CoV pneumonia study, patients had radiological sequelae in 33% of cases and the 12-month evaluation showed persistence of radiological abnormalities in 23.7% of the cases despite an improvement in respiratory function.
Clinical presentation and therapeutic management of severe SARS-CoV-2 infection are in part similar to those induced by SARS-CoV and MERS-CoV. Long-term respiratory complications are therefore expected.
详细描述
Objective is to evaluate prevalence of long-term respiratory complications after severe SARS-CoV2 pneumonia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patient
- •Patient with with severe SARS-CoV2 pneumonia
- •Patient consenting to participate to the study
- •Patient enrolled in the national healthcare insurance program
排除标准
- •Patient under 18 years
结局指标
主要结局
medium-term respiratory complications
时间窗: 3 months
Interstitial lung disease diagnosed with a thoracic CT-scan
次要结局
- long-term respiratory complications(12 months)