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临床试验/NCT05847712
NCT05847712已完成不适用

Safe Maximum Work Times and the Effectiveness of Work-rest Allocations in Mitigating Increases in Core Temperature During and on the Day Following Prolonged Moderate-intensity Work in the Heat in Young and Older Workers

University of Ottawa2 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2023年6月8日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
60
试验地点
2
主要终点
Initial stay time

研究概览

简要总结

Workplaces rely on upper heat stress limits provided by the American Conference of Governmental Industrial Hygienists (ACGIH) to manage the health and safety of workers in hot environments. This is primarily achieved by interspersing work with rest periods, the length of which is dictated by environmental conditions and work intensity, to maintain core temperature at or below 38.0°C (equivalent to a 1°C increase in body core temperature above resting levels). However, these guidelines employ a "one size fits all" approach to exposure limits that does not consider individual variation between workers. Moreover, they fail to provide direction on the safe, initial stay times before these heat-mitigation controls should be employed (i.e., rest breaks) in conditions exceeding upper heat stress limits. While recent work has generated estimates of the initial stay times for young to older men before heat-mitigation controls are required for moderate-intensity work, this information is limited to a single work bout and does not consider a second work bout preceded by an extended rest period (e.g., lunch) or next day effects. This is a key consideration, as prolonged work in the heat has been shown to cause next-day impairments in heat dissipation in older men. Further, it remains unclear if the application of the prescribed ACGIH work-rest allocations thereafter would alleviate increases in core temperature for the duration of the work period (e.g., start of shift versus post-lunch period). This project will address these knowledge gaps by determining if refinements in initial stay times for moderate-intensity work (represents the average work effort of physically demanding occupations) in the heat (26°C wet-bulb globe temperature) may be required for young and older adults for i) a second work bout that is preceded by an extended rest period such as a lunch break, and ii) a work bout performed on the next day. This includes assessing the efficacy of the prescribed ACGIH work-rest allocations to mitigate increases in core temperature beyond safe limits (>38.0°C, equivalent to a >1°C increase in body core temperature above resting levels) during these work periods. Given the known sex-differences in heat loss that can modulate core temperature regulation during an exercise-heat stress, the investigators will conduct separate analysis to identify modulating effects of biological sex on the initial stay times and effectiveness of the work-rest allocation as a heat-alleviation control.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
Single (Outcomes Assessor)

盲法说明

Data will be blinded prior to analysis

入排标准

年龄范围
18 Years 至 69 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • young (18-30 years) and older adults (50-69 years)
  • habitually active, not endurance trained (<2 sessions per week, <150 minutes per week)
  • non-smoking
  • English or French speaking
  • ability to provide informed consent

排除标准

  • pre-existing health conditions (e.g., diabetes, hypertension)
  • use of medication deemed to significantly modulate thermoregulatory function and heat tolerance (e.g., antidepressants, antihistamines, diuretics)
  • engaged in jobs and/or activities that involve frequent exposure to hot environments (e.g., regular sauna use)

结局指标

主要结局

Initial stay time

时间窗: End of third (morning day 2) continuous work bout

Total continuous work time to achieve an initial absolute increase in core temperature of 38°C (equivalent to a 1°C increase in body core temperature above resting levels) (note: in instances where a participant voluntarily terminates work prematurely before the absolute core temperature of ≥38°C (or relative increase of ≥1°C) is achieved or the absolute core temperature is \<38°C (or relative increase of \<1°C), the time of termination or end of the work bout will be taken as the initial stay time respectively).

Average core temperature

时间窗: Period of work-rest allocations following initial stay time for morning day 2

Average core temperature following initial stay time

次要结局

  • Average skin temperature(Period of work-rest allocations following initial stay time for morning day 2)
  • Skin temperature at initial stay time(End of third (morning day 2) continuous work bout)
  • Systolic blood pressure(End of third (morning day 2) work period)
  • Rate pressure product(End of third (morning day 2) work period)
  • Orthostatic Intolerance Symptoms Assessment(Period of work-rest allocations following initial stay time for morning day 2)
  • Heart rate at initial stay time(End of third (morning day 2) continuous work bout)
  • Fluid loss(End of third (morning day 2) work period)
  • Change in plasma volume(End of third (morning day 2) work period)
  • Thirst sensation scale(Period of work-rest allocations following initial stay time for morning day 2)
  • Average heart rate(Period of work-rest allocations following initial stay time for morning day 2)
  • Diastolic blood pressure(End of third (morning day 2) work period)
  • Mean arterial blood pressure(End of third (morning day 2) work period)
  • Fluid consumption(End of third (morning day 2) work period)
  • Rating of Perceived Exertion(Period of work-rest allocations following initial stay time for morning day 2)
  • Thermal comfort scale(Period of work-rest allocations following initial stay time for morning day 2)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Glen P. Kenny

Full Professor, University Research Chair

University of Ottawa

研究点 (2)

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