Comparison of the effect of Hibiscus sabdariffa L. extract and thiazide on treatment of hypertension in patients with mild chronic kidney disease : A randomized controlled clinical trial: double blinded

Phase 3

Recruiting

• Conditions: Patients with hypertension with mild renal failer.; Hypertensive chronic kidney disease

• Registration Number: IRCT20210926052600N1
• Lead Sponsor: Gorgan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 January 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

1. Non-pregnant man or woman 18 to 70 years old
2. Consent to participate in the study
3. A patient with confirmed clinical signs of hypertension with mild renal failure
4. Abnormal blood pressure (=> 130/80 according to AHA criteria)
5. Patient follow-up

Exclusion Criteria

1- Allergy to the plant
2- Normal blood pressure (mm HgSBP = 120; DBP = 80 mm Hg) / blood pressure below 100 and blood pressure => 160/100
3- Patients with diabetes mellitus, severe renal failure, coronary artery disease, heart failure, malignant hypertension [BP = 180/110], etc.)
4- Study of changing antihypertensive drugs in patients
5- Systolic blood pressure below 100 during the study
6- Pregnancy
7. Any metabolic or malabsorption disease that may interfere with the absorption of hibiscus (such as celiac disease, chronic pancreatitis, etc.).
8- Use of psychiatric drugs (mood stabilizer, anti-depressant, anti-anxiety or anti-psychotic

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patients' blood pressure changes,, albuminuria and proteinuria. Timepoint: Blood pressure at the beginning and 3 months after the intervention. Method of measurement: Based on laboratory Examination.;Electrolytes. Timepoint: Electrolytes at the beginning and 3 months after the start of the intervention. Method of measurement: Based on laboratory Examination.;Albuminuria and proteinuria. Timepoint: albuminuria, proteinuria, GFR according to MDRD formula. Method of measurement: Based on laboratory Examination.