Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Exercise; Other: Fasting

• Registration Number: NCT00817440
• Lead Sponsor: University of Aarhus

Brief Summary

Hypothesis: under fasting there will primarily be an activation of growth hormone(GH) signalpathways and a inhibition of insulin signalpathways, and the opposite will happen under physical activity.

Primarily we will investigate markers for GH and insulin signaltransduction in muscle- and fat-biopsies after fasting for 72 hours and after 1 hour of ergometer-cycling at 65% Vo2max.

In addition to this we will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-12
• Study First Submitted: 2009-01-05
• Study First Submitted QC: 2009-01-05
• Study First Posted: 2009-01-06
• Primary Completion: 2009-05
• Status Verified: 2011-01
• Last Update Submitted: 2011-01-10
• Last Update Posted: 2011-01-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

• healthy men
• Body mass index (BMI) 20-26
• age 18-45 years

Exclusion Criteria

• any kind of disease
• any use of medicine

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Exercise	Exercise	1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.
Fasting	Fasting	3 days of fasting and then the same as arm 1

Primary Outcome Measures

Name	Time	Method
Growth hormone and insulin signal pathways	30 min

Secondary Outcome Measures

Name	Time	Method
aminoacid and glucose turnover	4 hours

Trial Locations

Locations (1)

Aarhus sygehus; 🇩🇰 Aarhus, Jylland, Denmark