Effect of Dual Site-dual Channel Non-invasive Brain Stimulation for Recovery of Language and Cognitive Function in Stroke Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Changes in Korean Western Aphasia Battery
研究概览
简要总结
The aim of this study is to investigate the effect of dual site-dual channel non-invasive brain stimulation for recovery of language and cognitive function in post stroke patients. Simultaneous dual site-dual channel stimulation was applied by using two sets of transcranial direct current stimulation devices. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) Dual stimulation: i) anodal stimulation on ipsilesional inferior frontal cortex, ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex. 2) Single stimulation 1: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional inferior frontal cortex; 3) Single stimulation 2: anodal stimulation on ipsilesional inferior frontal cortex and cathodal stimulation on contralesional supraorbital area.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •left hemisphere involved stroke patients
- •patients diagnoses as post stroke aphasia
排除标准
- •history of psychiatric disease
- •patients with metal implants
- •history of epilepsy
- •pregnancy
- •skin defect at the site of electrode attachment
研究组 & 干预措施
Dual stimulation
i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional supraorbital area ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex and cathodal stimulation of contralesional supraorbital area
干预措施: IFG stimulation (Device)
Dual stimulation
i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional supraorbital area ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex and cathodal stimulation of contralesional supraorbital area
干预措施: DLPFC stimulation (Device)
Dual stimulation
i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional supraorbital area ii) anodal stimulation on ipsilesional dorsolateral prefrontal cortex and cathodal stimulation of contralesional supraorbital area
干预措施: aphasia therapy (Behavioral)
Single stimulation 1
i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional inferior frontal cortex
干预措施: IFG stimulation (Device)
Single stimulation 1
i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional inferior frontal cortex
干预措施: aphasia therapy (Behavioral)
Single stimulation 2
i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional supraorbital area
干预措施: IFG stimulation (Device)
Single stimulation 2
i) anodal stimulation of ipsilesional inferior frontal cortex and cathodal stimulation of contralesional supraorbital area
干预措施: aphasia therapy (Behavioral)
结局指标
主要结局
Changes in Korean Western Aphasia Battery
时间窗: Baseline and after intervention (approximately 2 weeks)
assessment of language function and provide aphasia quotients
Changes in Korean Boston naming test
时间窗: Baseline and after intervention (approximately 2 weeks)
measures naming ability thorough picture naming test
次要结局
- Digit span test(Baseline and after intervention (approximately 2 weeks))
- Changes in brain activation of resting-state and task functional MRI(Baseline and after intervention (approximately 2 weeks))
- Changes of Cortical activation(Baseline and after intervention (approximately 2 weeks))
- Korean Color Word Stroop test(Baseline and after intervention (approximately 2 weeks))
- Korea Montreal Cognitive Assessment(Baseline and after intervention (approximately 2 weeks))
- Controlled Oral Word Association Test(Baseline and after intervention (approximately 2 weeks))