The Effect of General Anesthesia and General Anesthesia Combined With Thoracic Epidural Anesthesia on Neuromuscular Block

Brief Summary

Detailed Description

The study was carried out with patients who were evaluated preoperatively in the Department of Anesthesiology and Reanimation, Department of Anesthesiology, Faculty of Medicine, Yuzuncu Yıl University. Sixty ASA I-II group patients, aged between 18-65 and scheduled for gastric ca operation, were included in the study. Severe heart, lung, liver disease, kidney failure, bleeding diathesis, fever, infection, allergy to drugs to be used, those who refused to participate in the study, patients with hypothermic and acid-base disorders, electrolyte disorders such as hypokalemia, hypocalcemia, antibiotics, anticonvulsants, Those taking antiarrhythmic and cholinesterase inhibitors were excluded from the study. The cases were divided into 2 groups by the envelope method, 30 people will be included in the general anesthesia group (GA), and 30 people will be included in the general anesthesia and thoracic epidural anesthesia group (GAE). After the patients who did not receive premedication were taken to the operating room, standard monitoring was provided with ECG, non-invasive arterial pressure, peripheral oxygen saturation. Peripheral vein cannulation was performed with a 20 gauge i.v. catheter, and a 4 mL/kg 0.9% NaCl infusion was started. In Group GAE, after preoperative asepsis was achieved, cutaneous-subcutaneous local anesthetic was infiltrated through the T7-9 space. The epidural space was determined by the loss of resistance method with a 16 gauge Tuohy epidural needle, and an 18 gauge epidural catheter was placed in the epidural space at a 4 cm angle in the cranial direction. The location of the catheter was confirmed by applying a test dose of 3 mL 2% lidocaine containing 5μ/ml adrenaline. After 5 minutes, 5 ml of 0.125% bupivacaine was given and the patient was placed in the supine position immediately afterwards. Electrodes were placed for TOF monitoring after thoracic epidural catheterization in the GAE group. Anesthesia induction was applied to all patients with 1mg/kg lidocaine, 1μcg/kg fentanyl, 2mg/kg propofol, 0.6mg/kg rocuronium. When the Train of four (TOF) value was 0, patients were intubated with an endotracheal tube (7-7.5 endotracheal tube (ETT) for women, 8-8.5 ETT for men). In maintenance, desflurane at 8% concentration was applied in a mixture of 50% O2 + 50% air. The time to reach 25% of the TOF value for both groups was noted. 0.1mg/kg rocuronium was added to patients who reached 0.25. The number of additional muscle relaxant requirements was recorded. In the GAE group, 5 ml of epidural drug was given every hour. In the GA group, 0.05mg/kg morphine was given 30 minutes before the end of the operation. Considering the time it took for the TOF value to reach 70%, the inhaler anesthetics were terminated and the patients with a TOF value of 90% were extubated. Patient enrollment was conducted between June 2023 and January 2024.

Primary Outcomes