Evaluation of Malondialdehyde in Periodontal and Cardiovascular Disease

Completed

• Conditions: Metabolic Disease
• Interventions: Other: Observation

• Registration Number: NCT04030286
• Lead Sponsor: University of Messina

Brief Summary

Malondialdehyde (MDA) plays a key role in endothelial function and may be a link for the known interaction of periodontitis and coronary heart disease (CHD). The investigators compared the impact of gingival health, periodontitis (CP), CHD or of both diseases (CP+CHD) on saliva and serum MDA levels.

Detailed Description

The aim of this study was to evaluate a possible association between both saliva and serum MDA levels in patients with CP and with CHD and if the serum MDA levels are mediated by serum CRP

Study Timeline

• Study Start: 2014-01-03
• Primary Completion: 2018-09-09
• Study Completion: 2019-04-01
• Status Verified: 2019-07
• Study First Submitted: 2019-07-19
• Study First Submitted QC: 2019-07-19
• Last Update Submitted: 2019-07-19
• Study First Posted: 2019-07-23
• Last Update Posted: 2019-07-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 133

Inclusion Criteria

• Presence of at least twenty teeth

• CP with a minimum of 40% of sites with a clinical attachment level (CAL)

  ≥2mm and probing depth (PD) ≥4mm;

• Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs

• Presence of ≥40% sites with bleeding on probing (BOP)

Exclusion Criteria

• Intake of contraceptives
• Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
• Status of pregnancy or lactation
• Previous history of excessive drinking
• Allergy to local anaesthetic
• Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Periodontitis	Observation	Patients with periodontal disease
Cardiovascular	Observation	Patients with cardiovascular disease
Control	Observation	Healthy patients
Periodontitis+Cardiovascular	Observation	Patients with both periodontal and cardiovascular disease

Primary Outcome Measures

Name	Time	Method
Malondialdehyde levels	1 year

Trial Locations

Locations (1)

University of Messina; 🇮🇹 Messina, Italy