Microvascular dysfunction in malignant hypertension; evaluation of the endothelial glycocalyx.
- Conditions
- hypertensive crisis10057166
- Registration Number
- NL-OMON32232
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Age between 18 and 99 years
Blood pressure above 120 mmHg diastolic on repeated examination
Admission for parenteral bloodpressure lowering treatment with labetalol
Exclusion Criteria
Current pregnancy
Intoxications (e.g. cocaine, XTC)
Hypertensive crises treated with other oral or parenteral drugs than labetalol
Contra-indication for beta or alpha blockers.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Microvascular glycocalyx volume changes</p><br>
- Secondary Outcome Measures
Name Time Method <p>Coagulation activation<br /><br>Endothelial activation<br /><br>Glycocalyx degradation products<br /><br>Oxidative stress measurements</p><br>