Pathogenesis of Functional Hypothalamic Amenorrhea
Not Applicable
Completed
- Conditions
- Hypersecretion; CortisolMetabolic DisturbanceStress, PsychologicalDisorder of Endocrine Ovary
- Registration Number
- NCT01674426
- Lead Sponsor
- University of Pittsburgh
- Brief Summary
This is a randomized pilot study of the use of cognitive behavior therapy versus observation to treat functional hypothalamic amenorrhea, often termed stress-induced anovulation.
- Detailed Description
The study enrollment was completed in 2003. The study results are being analyzed.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 17
Inclusion Criteria
- women with functional hypothalamic amenorrhea
- day awake / night asleep schedule
Exclusion Criteria
- eating disorders, depression, excessive exercise or any other cause of amenorrhea and anovulation other than functional hypothalamic amenorrhea
- weight loss greater than 10 pounds when amenorrhea developed
- running more than 10 miles per week or exercising more than 10 hours per week
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method ovarian function Change before and after 20 weeks of CBT or observation The change in ovarian function was assessed by comparing ovarian function before and after 20 weeks of CBT or observation using menses and serial estradiol and progesterone level as indices of ovarian function
- Secondary Outcome Measures
Name Time Method metabolism Change before and after 20 weeks of CBT or observation The change in metabolism was assessed by measuring levels of cortisol, TSH, T4, free T4, T3, free T3, leptin in blood and by measuring weight before and after 20 weeks of CBT or observation
Trial Locations
- Locations (1)
UPittsburgh
🇺🇸Pittsburgh, Pennsylvania, United States
UPittsburgh🇺🇸Pittsburgh, Pennsylvania, United States