Identification of individual cancer mutations and analysis of their immunogenicity

Not Applicable

Recruiting

Conditions: cancer
C00-C97
Malignant neoplasms

Registration Number: DRKS00011790

Lead Sponsor: BioNTech SE

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 1000

Inclusion Criteria

signed informed consent; Health condition, that allows planned interventions (according clinical standards);
Hemoglobin value = 10,0 g / dl;
Patient with suspected/confirmed malign tumor with either already excised/planned excision of tumor material and/or possibility of tumor biopsies exclusively taken for the research project

Exclusion Criteria

Known pregnancy or breastfeeding;
Known acute or chronically active hepatitis infection, known HIV infection;
Patients who are incapable to give consent or are not able to understand the nature of the project;
serious concomitant disease or other circumstances (e.g. psychological, familial, sociological or geographical circumstances), which do not allow an adequate participation

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The aim of this research project is to gain a profound understanding of genetic alterations within tumors as well as the tumor immunology of several entities (via histological, genetic and immunological analysis of tissue and blood samples) and to use this knowledge for further development of individualized cancer immunotherapies.

Secondary Outcome Measures

Name	Time	Method
The secondary outcome is to establisch and optimize processes and methods. One aim is to be able to perform analytical procedures in the future (a) with small amounts of tumor material or (b) without tomur tissues.