Prenatal exposure to intra-amniotic infection with Ureaplasma species increases the prevalence of bronchopulmonary dysplasia.

Not Applicable

• Conditions: Intra-amniotic infection

• Registration Number: JPRN-UMIN000052298
• Lead Sponsor: ational Hospital Organization, Saga National Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-12-10
• Study Start: 2023-09-25
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: Female
• Target Recruitment: 209

Inclusion Criteria

Not provided

Exclusion Criteria

Exclusion criteria were as follows: delivery after 34 gestational weeks, fetal chromosomal abnormalities or multiple malformations, intrauterine fetal death, delivery at another hospital, MIAC in which Ureaplasma spp. and Mycoplasma hominis were not identified, and an unclear placental pathology or umbilical vein blood interleukin (IL)-6 concentration in patients in whom intra-amniotic inflammation or MIAC was not detected by amniocentesis or for whom amniocentesis was not indicated.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary study outcomes were the relationships between the prevalence of BPD and intra-amniotic infection with or without Ureaplasma spp. and intra-amniotic inflammation without MIAC after adjusting for gestational age at birth.

Secondary Outcome Measures

Name	Time	Method
Secondary study outcomes were the relationships between the prevalence of adverse neonatal outcomes, and intra-amniotic infection with or without Ureaplasma spp. and intra-amniotic inflammation without MIAC after adjusting for potential confounders.