Comparison of Morning or Evening Antihypertensive Drugs on Albuminuria (The MORE trial): A Randomized Control Trial
- Conditions
- patients with hypertension presenting albuminuria more than 30 mg/g and taking more than one antihypertensive class more than 3 monthsalbuminuria, albumin creatinine ratio, evening, hypertension, morning
- Registration Number
- TCTR20220722005
- Lead Sponsor
- avamindradhiraj University, Thailand
- Brief Summary
Treatment of hypertension with either morning or evening dose regimen did not impact UACR or reduce blood pressure
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 58
Age 18-80 year
Hypertension for more than 1 year
At least one antihypertensive agent for more than 3 months and at least one antihypertensive agent in Angiotensin-converting enzyme inhibitor (ACEI) and/or Angiotensin receptor blocker (ARB)
Well controlled blood pressure (systolic blood pressure < 150 mmHg, Diastolic blood pressure < 90 mmHg)
albuminuria > 30 mg/g
Renal function (estimated glomerular filtration rate, eGFR > 15 ml/min/1.73 m2)
End stage kidney disease
Poor control blood pressure
Severe comorbid disease for example congestive heart failure, active cancer
Pregnancy
Inflammatory disease or active infection for example arthritis, pyelonephritis
Study termination criteria
Flare of comorbid disease or active infection (Cancer, acute coronary syndrome or any underlying disease that effect renal function) after included in study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method rine albumin creatinine ratio 3 months after intervention UACR
- Secondary Outcome Measures
Name Time Method Effect to serum creatinine 3 months after intervention serum creatinine ,Effects of blood pressure 3 months after intervention Systolic and diastolic blood pressure