Association Between ΜFR and CABG Outcomes

Active, not recruiting

• Conditions: Coronary Artery Bypass Graft Surgery (CABG)

• Registration Number: NCT06844721
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The goal of this observational study is to evaluate the association between Murray law-based quantitative flow reserve and outcomes after coronary artery bypass graft surgery.

Detailed Description

The goal of this observational study is to evaluate the association between Murray law-based quantitative flow reserve and outcomes after coronary artery bypass graft surgery. By constructing registry database during 10-year periods, several types of study objectives including 'graft patency' and 'long-term clinical outcomes' will be evaluated.

Study Timeline

• Study Start: 2008-01-01
• Status Verified: 2025-02
• Study First Submitted: 2025-02-15
• Study First Submitted QC: 2025-02-19
• Last Update Submitted: 2025-02-19
• Study First Posted: 2025-02-25
• Last Update Posted: 2025-02-25
• Primary Completion: 2025-03-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 945

Inclusion Criteria

1. patients who underwent isolated off-pump CABG for 3-vessel disease,
2. patients who underwent preoperative coronary angiography that fits for μFR analysis,

Exclusion Criteria

1. Patients who underwent on-pump CABG
2. Patients in whom quality of preoperative coronary angiography did not fit for μFR analysis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Graft patency rate	1 year after surgery	1 year graft patency rate after surgery
Number of participants with Long-term all-cause mortality	From date of enrollment (operation) until the date of death from any cause, assessed up to 15 years").	All-cause mortality indicates death from any cause during follow-up

Secondary Outcome Measures

Name	Time	Method
Number of partipiciants with major adverse cardiac events	From date of enrollment (operation) until the date of first documented major events or date of death from any cause, whichever came first, assessed up to 15 years	MACE includes death, repeat revascularization and non-fatal myocardial infraction

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of