Characterization of human and microbial genetic components in normal colon tissue, colorectal adenomas, saliva and fecal samples

Completed

• Conditions: Colonic polyps; microbiome; 10017990

• Registration Number: NL-OMON43246
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 600

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:
* Scheduled for a regular colonoscopy
* Aged 18 years or above
* Colonoscopy schedualed for one of the following indications:
o Positive FOBT (Fecal Occult Blood Test) outside of the national screening program for colorectal cancer
o Follow up after polypectomy or colorectal cancner
o Rectal blood loss or anemia
o Abdominal pain
o Familial history of colon cancer or adenoma
o Abnormal radiologic imaging of the colonsuch as barium enema or CT colonography
o Change in bowel habits
* Singed informed consent

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:
* Previous surgical bowel resection, except from appendectomy
* Known or suspicion of inflammatory bowel disease.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study endpoint is the composition and abundance of microbiota<br /><br>genomic and transcriptomic components in healthy and adenoma mucosal samples as<br /><br>well as stool and saliva. </p><br>