Ischemic Preconditioning in Osteoarthritis and Back Pain

Not Applicable

Not yet recruiting

• Conditions: Low Back Pain; Knee Osteoarthritis

• Registration Number: NCT07003113
• Lead Sponsor: University of Illinois at Chicago

Brief Summary

We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee osteoarthritis and low back pain.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-05-23
• Status Verified: 2025-06
• Study First Submitted QC: 2025-06-02
• Last Update Submitted: 2025-06-02
• Study First Posted: 2025-06-04
• Last Update Posted: 2025-06-04
• Study Start: 2025-07-01
• Primary Completion: 2026-07-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Reported Knee Pain using ACR Criteria
• Reported Back Pain using ODI Criteria > 12
• Ability to walk for at least 3 minutes without the use of aids
• Ability to provide written informed consent

Exclusion Criteria

• Younger than 50 years old
• History of Knee or Hip Replacements
• History of steroid injection within the previous 6 months
• Presence of neuromuscular joint condition that affects lower extremity function
• History of blood clots in the leg or any condition in which compression of the thigh is contraindicated
• History of heart failure or thrombosis
• Allergic to ultrasound gel
• History of spine surgery
• Non-English speaker
• Currently pregnant or intends to become pregnant during the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Preferred walking speed	At baseline (from enrollment) until end of intervention (3 weeks).	Changes in preferred walking speed (m/s) from intervention
Muscle strength	From baseline (enrollment) until end of intervention (3 weeks)	Change in quadriceps, hamstring, and hip strength
Patient Reported Outcomes	At baseline (enrollment) through the intervention (3 weeks)	Change in subjective function and reporting based on questionnaires
Gait Kinematics	At baseline (from enrollment) until end of intervention (3 weeks).	Changes in gait kinematics (in degrees) from intervention
Gait Kinetics/Moments	At baseline (from enrollment) until end of intervention (3 weeks).	Changes in gait kinetics (joint moments) (in N/m) from intervention

Secondary Outcome Measures

Name	Time	Method
Cartilage Health	From baseline (enrollment) until completion of intervention (3 weeks)	Change in knee cartilage thickness using ultrasound methods

Trial Locations

Locations (1)

Human and Sport Performance Lab; 🇺🇸 Chicago, Illinois, United States