ISRCTN22322271已完成未知
A phase I/II study to investigate the safety of adenovirus-specific T-cells given to high-risk paediatric patients post allogeneic haematopoietic stem cell transplant (HSCT) to prevent or treat reactivation of adenovirus
Cell Medica Ltd (UK)0 个研究点目标入组 8 人开始时间: 2012年4月12日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 8
研究概览
简要总结
2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/29753677 (added 16/04/2019)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Age 16 years or younger
- •2. Scheduled to undergo an allogeneic HSCT with an unrelated donor, mismatched unrelated donor, mismatched family donor or haplo identical donor
- •3. The subject (or legally acceptable representative) must give informed consent (and assent for subjects = 12 years). All subjects will have a parent or guardian provide informed consent and the subject will provide witnessed verbal assent
- •4. Negative serology for HIV 1 + 2, HepB, HepC, Syphilis, hCG.
- •Donors (for manufacturing only):
- •1. Meets requirements of Directive 2004/23/EC as amended and the UK statutory instruments pursuant therein
- •2. Negative serology for HIV 1 + 2, HepB, HepC, Syphilis, hCG
- •3. Passed medical assessment for stem cell donation
- •4. HdADV seropositive
- •5. Signed informed consent
- •6. Age 16 years or older
排除标准
- •1. Pregnant or lactating females
- •2. Co-existing medical problems that would place the patient at significant risk of death due to GVHD or its sequelae
- •3. Human Immunodeficiency Virus (HIV) infection
- •1. Pregnant or lactating females
- •2. (assessed prior to apheresis) Platelets < 50x109/L
研究者
相似试验
已完成
2 期
A study of the drugs AZD2014 and rituximab in relapsed or refractory diffuse large B-cell lymphomaTopic: CancerSubtopic: LymphomaDisease: Lymphoma (other)CancerISRCTN10760016niversity of Birmingham36
已完成
1 期
Efficacy and safety of olaparib in relapsed and refractory chronic lymphocytic leukaemia patients with an 11q deletion or ATM mutation and relapsed/refractory patients with T-prolymphocytic leukaemia and mantle cell lymphomaChronic lymphocytic leukaemiaLymphoid leukaemiaCancerISRCTN34386131niversity of Birmingham (UK)15
已完成
4 期
Small volume resuscitation with albumin in intensive careSpecialty: Critical care, Primary sub-specialty: Critical CareUKCRC code/ Disease: Generic Health Relevance/ No specific diseaseCirculatory SystemHypovolaemiaISRCTN15839026Central Manchester University Hoapitals NHS Foundation Trust321
已完成
不适用
A trial of antipsychotic medication in comparison to cognitive behaviour therapy or a combination of both in adults with psychosisTopic: Mental Health Research NetworkSubtopic: Schizophrenia, PsychosisDisease: Schizophrenia, PsychosisMental and Behavioural DisordersSchizophreniaISRCTN06022197Greater Manchester West Mental Health NHS Foundation Trust (UK)75
已完成
不适用
Efficacy of patient-controlled paravertebral block for single intercostal video assisted thoracic surgeryPain in the postoperative periodSigns and SymptomsISRCTN24097424Second Affiliated Hospital of Zhejiang University260