Effects of resistance training and animal protein intake on diet?induced weight loss in obese older women displaying metabolic abnormalities

Completed

• Conditions: Obesity, menopause, metabolic syndrome, physical capacity.; Nutritional, Metabolic, Endocrine; Obesity

• Registration Number: ISRCTN51723391
• Lead Sponsor: niversity of Sherbrooke (Canada)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-25
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

1. Women will be included in the study if they had stopped menstruating for more than 1 yr, and if they have follicle stimulating hormone (FSH) levels > 30 U/L
2. Aged between 60 and 75 years old
3. Body mass index (BMI) between 27 and 40 kg/m2
4. Sedentary (< 2 times a week of exercise)
5. Non-smokers
6. Low to moderate alcohol consumers (< 2 drinks/week)
7. Displaying at least one of the following factor of the metabolic syndrome accordingly to the Adult Treatment Panel III (ATP III?s) definition [63] [triglycerides > 1.70 mmol/L; high density lipoprotein (HDL)-cholesterol < 1.29 mmol/L; resting blood pressure < 160/95 mmHg (treated or not); fasting plasma glucose > 6.1 mmol/L], 7) stable medication(s) for the metabolic syndrome since 6 weeks and
8. Glycated haemoglobin (HbA1c) < 8%

Exclusion Criteria

1. More than three medications for high blood pressure
2. Cardiovascular disease and peripheral vascular disease within 3 months
3. Stroke within 3 months and/or causing inability to complete the exercice program
4. Diabetes treated with insulin
5. Cancer within 5 years (excepted skin and thyroid cancer)
6. Severe hypertension (resting blood pressure > 160/95 mmHg under stable treatement)
7. Total cholesterol > 8 mmol/L
8. Triglycerides >10 mmol/L
9. Low density lipoprotein (LDL)-chol > 4 mmol/L
9. Body weight fluctuation > 3 kg in the previous six months
10. Pituitary disease
11. Renal insufficiency (creatine <45 ml/min)
12. Orthopaedic problems causing inability to complete the exercice program
13. Protein intake <0.8 g/kg or >1.2 g/kg body mass per day

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Dual energy X-ray absorptiometry (DXA) technology to measure total fat mass, bone mass and lean body mass as well as each tissue by region (trunk, legs and arms). <br>2. Other measures of body composition include weight, height, waist and hip circumferences. They are taken before, during and after the intervention (total of 3 times for DXA outcomes and 8 times for other body composition measurements).