Comparison of propofol intravenous anesthetic and Isoflurane inhalational anesthetic on QTc interval in ECG of patients receiving methadone maintenance therapy who are candidate for open limbs surgery.
Phase 3
- Conditions
- Open reduction and internal fixation of limbs under general anesthesia in methadone maintenance treatment patients..Fracture of shaft of radiusS52.4
- Registration Number
- IRCT20200524047560N1
- Lead Sponsor
- Shahroud University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 60
Inclusion Criteria
Male
Age 18 - 60
Methadone maintenance therapy with a dose of at over 50 mg per day
Open limbs surgery under general anesthesia
Class 1 and 2 of anesthesia risk (According to American society of anesthesiologist's classification)
Normal preoperative heart rate and rhythm
Exclusion Criteria
Use of every drug except methadone in last week
Moderate and severe systemic disorders( anesthesia risk over 2)
Every abnormal heart rate and rhythm
Need for injection of a drug that changes routine anesthesia protocol.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method QT interval. Timepoint: Preoperative - 20 minutes after induction of anesthesia - After recovery. Method of measurement: Record of lead_2 of electrocardiogram.;Pulse rate. Timepoint: Preoperative - 20 minutes after induction of anesthesia - After recovery. Method of measurement: Record of lead_2 of electrocardiogram.
- Secondary Outcome Measures
Name Time Method Corrected QT. Timepoint: Preoperative- 20 minutes after induction of anesthesia- end of recovery. Method of measurement: QTc calculator software using QT and pulse rate.