Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer
- Conditions
- Small Cell Lung Cancer (SCLC)
- Interventions
- Registration Number
- NCT05740566
- Lead Sponsor
- Amgen
- Brief Summary
The main objective is to compare the efficacy of tarlatamab with standard of care (SOC) on prolonging overall survival (OS).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 509
- Participant has provided informed consent prior to initiation of any study specific activities/procedures.
- Age ≥ 18 years (or legal adult age within country, whichever is older) at the time of signing the informed consent.
- Histologically or cytologically confirmed SCLC with demonstrated progression or relapse.
- Participants who progressed or recurred following 1 platinum-based regimen.
- Measurable disease as defined per RECIST 1.1 within the 21-day screening period.
- Eastern Cooperative Oncology Group (ECOG) PS of 0 or 1.
- Minimum life expectancy of 12 weeks.
- Adequate organ function.
-
Disease Related
- Symptomatic central nervous system (CNS) metastases with exceptions defined in the protocol.
- Diagnosis or evidence of leptomeningeal disease.
- Prior history of immune checkpoint inhibitors resulting in events defined in the protocol.
-
Other Medical Conditions
- Active autoimmune disease that has required systemic treatment (except replacement therapy) within the past 2 years or any other diseases requiring immunosuppressive therapy.
- History of solid organ transplantation.
- History of other malignancy within the past 2 years, with exceptions defined in the protocol.
- Myocardial infarction and/or symptomatic congestive heart failure (New York Heart Association > class II) within 12 months prior to first dose of study treatment.
- History of arterial thrombosis (eg, stroke or transient ischemic attack) within 12 months prior to first dose of study treatment.
- Presence or history of viral infection based on criteria per protocol.
- Receiving systemic corticosteroid therapy or any other form of immunosuppressive therapy within 7 days prior to first dose of study treatment.
- Symptoms and/or radiographic signs that indicate an acute and/or uncontrolled active systemic infection requiring antibiotics within 7 days prior to the first dose study treatment.
- Evidence of interstitial lung disease or active, non-infectious pneumonitis.
-
Prior/Concomitant Therapy
- Prior therapy with tarlatamab or any of the standard of care chemotherapy included as part of this trial or participation in any tarlatamab or any other DLL3 targeted agent clinical trial.
- Prior therapy with any selective inhibitor of the DLL3 pathway.
- Participant received more than one prior systemic therapy regimen for SCLC.
- Prior anti-cancer therapy within 21 days prior to first dose of study treatment with exceptions defined in protocol.
- Current anti-cancer therapy such as chemotherapy, immunotherapy, or targeted therapy with exceptions.
- Use of herbal or prescription/non-prescription medications known to inhibit membrane transporters P-glycoprotein (P-gp) and/or breast cancer resistance protein (BCRP) within 7 days prior to the first dose of study treatment.
- Use of herbal or prescription/non-prescription medications known to be moderate or strong inhibitors of cytochrome P450 3A (CYP3A) enzymes within 7 days prior to the first dose of study treatment.
- Use of herbal or prescription/non-prescription medications known to be moderate or strong inducers of CYP3A enzymes within 28 days prior to first dose of study treatment.
- Participants who have reached the limit dose of prior treatment with cardiotoxic drugs.
- Major surgical procedures within 28 days prior to first dose of study treatment.
- Live and live-attenuated vaccines within 14 days prior to the start of study treatment.
- Inactive vaccines and live viral non-replicating vaccines within 3 days prior to the first dose of study treatment.
- Currently receiving treatment in another investigational device or drug study, or less than 30 days since ending treatment on another investigational device or drug study(ies). Other investigational procedures while participating in this study are excluded.
-
Diagnostic Assessments
- Any previous diagnosis of transformed non-small cell lung cancer (NSCLC), epidermal growth factor receptor (EGFR) activating mutation positive NSCLC that has transformed to SCLC, with exceptions defined in the protocol.
-
Other Exclusions
- Female participants of childbearing potential unwilling to use protocol specified method of contraception during treatment and for an additional 60 days after the last dose of tarlatamab.
- Female participants who are breastfeeding or who plan to breastfeed while on study through 60 days after the last dose of tarlatamab.
- Female participants planning to become pregnant or donate eggs while on study through 60 days after the last dose of tarlatamab.
- Female participants of childbearing potential with a positive pregnancy test assessed at screening by a serum pregnancy test.
- Male participants with a female partner of childbearing potential who are unwilling to practice sexual abstinence (refrain from heterosexual intercourse) or use contraception during treatment and for an additional 60 days after the last dose of tarlatamab.
- Male participants with a pregnant partner who are unwilling to practice abstinence or use a condom during treatment and for an additional 60 days after the last dose of tarlatamab.
- Male participants unwilling to abstain from donating sperm during treatment and for an additional 60 days after the last dose of tarlatamab.
- Contraception requirements for male and female participants receiving SOC therapies are based on regional prescribing information.
- Breastfeeding restrictions for female participants receiving SOC therapies are based on regional prescribing information.
- Participant has known sensitivity or is contraindicated to any of the products or components to be administered during dosing.
- Participant likely to not be available to complete all protocol-required study visits or procedures, and/or to comply with all required study procedures.
- History or evidence of any other clinically significant disorder, condition or disease determined by the investigator or Amgen physician that would pose a risk to the subject safety or interfere with the study evaluation..
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Tarlatamab Tarlatamab Participants will receive tarlatamab as an intravenous (IV) infusion. Standard of Care Topotecan Participants will receive treatment per local standard of care (SOC). Standard of Care Lurbinectedin Participants will receive treatment per local standard of care (SOC). Standard of Care Amrubicin Participants will receive treatment per local standard of care (SOC).
- Primary Outcome Measures
Name Time Method Overall Survival (OS) Up to approximately 4 years
- Secondary Outcome Measures
Name Time Method Responses to Patient-Reported Adverse Events Questionnaire (PRO-CTCAE) Up to approximately 4 years PFS 1 year Change from Baseline in Selected Disease Symptoms Included in Lung Cancer Quality of Life Questionnaire (EORTC-QLQ-LC13) Up to approximately 4 years Duration of Response (DOR) Up to approximately 4 years Serum Concentrations of Tarlatamab Up to 1 year Overall Response (OR) Up to approximately 4 years Incidence of Treatment-Emergent Adverse Events (TEAE) Up to approximately 4 years Change from Baseline in Pain Severity as Measured by Brief Pain Inventory - Short Form (BPI-SF) Up to approximately 4 years Progression Free Survival (PFS) Up to approximately 4 years Disease Control (DC) Up to approximately 4 years OS 1 year, 2 years and 3 years Number of Participants Who Experience Anti-tarlatamab Antibodies Up to 1 year Patient Perceived Health at Each Assessment Visit Using Visual Analogue Scale (VAS) Up to approximately 4 years Change from Baseline in Symptom Severity as Measured by Patient Global Impression of Severity (PGIS) Questionnaire Up to approximately 4 years Change from Baseline In Selected Functional Scales and Disease Symptom Items Included in Cancer Quality of Life Questionnaire (EORTC QLQ-C30) Up to approximately 4 years Change from Baseline in Patient Perceived Health Using Visual Analog Scale (VAS) Up to approximately 4 years Change from Baseline in Symptoms and Overall Status as Measured by Patient Reported Impression of Change (PGIC) Questionnaire Up to approximately 4 years Change from Baseline in Symptom Bother as Measured by Functional Assessment of Cancer Therapy - General (FACT-G) Questionnaire Up to approximately 4 years
Trial Locations
- Locations (223)
Vitaz campus Sint-Niklaas Moerland
🇧🇪Sint-Niklaas, Belgium
Beneficencia Portuguesa de Sao Paulo - Bp
🇧🇷Sao Paulo, São Paulo, Brazil
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp
🇧🇷São Paulo, Brazil
The 4th Hospital of Hebei Medical University
🇨🇳Shijiazhuang, Hebei, China
The First Affiliated Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, Zhejiang, China
Universitaetsklinikum Koeln
🇩🇪Koeln, Germany
Christie Hospital
🇬🇧Manchester, United Kingdom
Guys Hospital
🇬🇧London, United Kingdom
University College London Hospital
🇬🇧London, United Kingdom
Memorial Ankara Hastanesi
🇹🇷Ankara, Turkey
Fakultni nemocnice Brno
🇨🇿Brno, Czechia
Charite Universitaetsmedizin Berlin, Campus Virchow
🇩🇪Berlin, Germany
Saint Savas Hospital
🇬🇷Athens, Greece
Jiangmen Central Hospital
🇨🇳Jiangmen, Guangdong, China
Jinan Central Hospital
🇨🇳Jinan, Shandong, China
Shandong Tumor Hospital
🇨🇳Jinan, Shandong, China
Shanghai Chest Hospital
🇨🇳Shanghai, Shanghai, China
The Second Affiliated Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
Sendai Kousei Hospital
🇯🇵Sendai-shi, Miyagi, Japan
Hospital Santa Izabel
🇧🇷Salvador, Bahia, Brazil
Instituto de Ensino e Pesquisa do Hospital da Bahia
🇧🇷Salvador, Bahia, Brazil
Sanford Roger Maris Cancer Center
🇺🇸Fargo, North Dakota, United States
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Gyeonggi-do, Korea, Republic of
University of Arkansas for Medical Sciences
🇺🇸Little Rock, Arkansas, United States
Clinica Viedma
🇦🇷Viedma, Río Negro, Argentina
Medizinische Universitaet Graz
🇦🇹Graz, Austria
Sociedad de Beneficencia Hospital Italiano
🇦🇷Cordoba, Córdoba, Argentina
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
Baptist Cancer Center
🇺🇸Memphis, Tennessee, United States
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Hospital de Base de Sao Jose do Rio Preto
🇧🇷São José do Rio Preto, São Paulo, Brazil
Alaska Oncology and Hematology
🇺🇸Anchorage, Alaska, United States
Instituto Argentino de Diagnostico y Tratamiento IADT
🇦🇷Buenos Aires, Argentina
Alexandra Hospital
🇬🇷Athens, Greece
University Hospital of Heraklion
🇬🇷Heraklion - Crete, Greece
Our Lady of the Lake Cancer Institute
🇺🇸Baton Rouge, Louisiana, United States
Hospital da Luz, SA
🇵🇹Lisboa, Portugal
Cemic
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Hospital Universitario Austral
🇦🇷Pilar, Buenos Aires, Argentina
Thoracic General Hospital Of Athens Sotiria
🇬🇷Athens, Greece
Olympion Therapeftirio General Clinic Of Patras
🇬🇷Patra, Greece
Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz
🇭🇺Szekesfehervar, Hungary
Reformatus Pulmonologiai Centrum
🇭🇺Torokbalint, Hungary
Hadassah Ein-Kerem Medical Center
🇮🇱Jerusalem, Israel
National Hospital Organization Hokkaido Cancer Center
🇯🇵Sapporo-shi, Hokkaido, Japan
Hyogo Cancer Center
🇯🇵Akashi-shi, Hyogo, Japan
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center
🇯🇵Yokohama-shi, Kanagawa, Japan
Kansai Medical University Hospital
🇯🇵Hirakata-shi, Osaka, Japan
Saitama Medical University International Medical Center
🇯🇵Hidaka-Shi, Saitama, Japan
National Cancer Center Hospital
🇯🇵Chuo-ku, Tokyo, Japan
University of Tennessee Medical Center Knoxville
🇺🇸Knoxville, Tennessee, United States
Hospital de Amor da Amazonia
🇧🇷Porto Velho, Rondônia, Brazil
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Sanatorio Parque SA
🇦🇷Rosario, Santa Fe, Argentina
Sanatorio Allende
🇦🇷Córdoba, Argentina
AZ Delta Campus Rumbeke
🇧🇪Roeselare, Belgium
Matrai Gyogyintezet
🇭🇺Gyongyos, Hungary
Rambam Medical Center
🇮🇱Haifa, Israel
Meir Medical Center
🇮🇱Kfar Saba, Israel
Rabin Medical Center
🇮🇱Petah Tikva, Israel
National Cancer Center Hospital East
🇯🇵Kashiwa-shi, Chiba, Japan
Niigata Cancer Center Hospital
🇯🇵Niigata-shi, Niigata, Japan
Oncologia Rede D Or
🇧🇷Sao Paulo, São Paulo, Brazil
Orszagos Koranyi Pulmonologiai Intezet
🇭🇺Budapest, Hungary
Komarom-Esztergom Varmegyei Szent Borbala Korhaz
🇭🇺Tatabanya, Hungary
Kurume University Hospital
🇯🇵Kurume-shi, Fukuoka, Japan
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Wilayah Persekutuan, Malaysia
Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano
🇵🇹Matosinhos, Portugal
SC Oncomed SRL
🇷🇴Timisoara, Romania
European Interbalkan Medical Center
🇬🇷Thessaloniki, Greece
Henry Dunant Hospital Center
🇬🇷Athens, Greece
Osaka International Cancer Institute
🇯🇵Osaka-shi, Osaka, Japan
Kindai University Hospital
🇯🇵Osakasayama-shi, Osaka, Japan
Shizuoka Cancer Center
🇯🇵Sunto-gun, Shizuoka, Japan
The Cancer Institute Hospital of Japanese Foundation for Cancer Research
🇯🇵Koto-ku, Tokyo, Japan
Oncare
🇲🇽Ciudad de México, Distrito Federal, Mexico
National Cancer Centre Singapore
🇸🇬Singapore, Singapore
Veterans General Hospital - Taichung
🇨🇳Taichung, Taiwan
Beaumont Hospital
🇮🇪Dublin, Ireland
National Hospital Organization Shikoku Cancer Center
🇯🇵Matsuyama-shi, Ehime, Japan
Juntendo University Hospital
🇯🇵Bunkyo-ku, Tokyo, Japan
Health Pharma Professional Research SA de CV
🇲🇽Mexico City, Distrito Federal, Mexico
Universitair Medisch Centrum Utrecht
🇳🇱Utrecht, Netherlands
Centrum Pulmonologii i Torakochirurgii w Bystrej
🇵🇱Bystra, Poland
Kantonsspital Graubuenden
🇨🇭Chur, Switzerland
Kantonsspital Winterthur
🇨🇭Winterthur, Switzerland
Okayama University Hospital
🇯🇵Okayama-shi, Okayama, Japan
Wakayama Medical University Hospital
🇯🇵Wakayama-shi, Wakayama, Japan
Erasmus Medisch Centrum
🇳🇱Rotterdam, Netherlands
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
coi Centro Oncologico Internacional sapi de cv
🇲🇽Tlajomulco de Zúñiga, Jalisco, Mexico
Universitair Medisch Centrum Groningen
🇳🇱Groningen, Netherlands
Wielkopolskie Centrum Pulmonologii i Torakochirurgii imienia Eugenii i Janusza Zeylandow
🇵🇱Poznan, Poland
Kantonsspital Sankt Gallen
🇨🇭Sankt Gallen, Switzerland
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Hospital Tengku Ampuan Afzan
🇲🇾Kuantan, Pahang, Malaysia
University of Missouri Health Care
🇺🇸Columbia, Missouri, United States
The Medical College of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
National Cancer Center
🇰🇷Goyang-si Gyeonggi-do, Korea, Republic of
Universitaetsklinikum Krems
🇦🇹Krems, Austria
Calvary Mater Newcastle Hospital
🇦🇺Waratah, New South Wales, Australia
Trinity Health Saint Joseph Mercy Ann Arbor
🇺🇸Ann Arbor, Michigan, United States
Saint Luke Hospital
🇬🇷Thessaloniki, Greece
University of South Alabama Mitchell Cancer Institute
🇺🇸Mobile, Alabama, United States
University of Illinois Chicago
🇺🇸Chicago, Illinois, United States
Northwestern University
🇺🇸Chicago, Illinois, United States
Indiana University
🇺🇸Indianapolis, Indiana, United States
University of California Los Angeles
🇺🇸Santa Monica, California, United States
University of Iowa
🇺🇸Iowa City, Iowa, United States
Pikeville Medical Center
🇺🇸Pikeville, Kentucky, United States
University of Minnesota Cancer Center
🇺🇸Minneapolis, Minnesota, United States
Summit Medical Group, Overlook Oncology Center
🇺🇸Summit, New Jersey, United States
New York University Grossman School of Medicine and New York University Langone Hospitals
🇺🇸New York, New York, United States
Perlmutter Cancer Center at New York University Langone Hospital----Long Island
🇺🇸New York, New York, United States
Memorial Sloan Kettering Cancer Center
🇺🇸New York, New York, United States
Northport Veterans Affairs Medical Center
🇺🇸Northport, New York, United States
Swedish Cancer Institute Medical Oncology
🇺🇸Edmonds, Washington, United States
Monash Medical Centre
🇦🇺Clayton, Victoria, Australia
Jessa Ziekenhuis - Campus Virga Jesse
🇧🇪Hasselt, Belgium
Liga Norte-Riograndense Contra O Cancer
🇧🇷Natal, Rio Grande Do Norte, Brazil
Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda
🇧🇷Ijui, Rio Grande Do Sul, Brazil
London Health Sciences Centre
🇨🇦London, Ontario, Canada
Instituto Coi
🇧🇷Rio de Janeiro, Brazil
Princess Margaret Cancer Centre
🇨🇦Toronto, Ontario, Canada
Anhui Chest Hospital
🇨🇳Hefei, Anhui, China
The Second Affiliated Hospital of Army Medical University, PLA
🇨🇳Chongqing, Chongqing, China
Beijing Cancer Hospital
🇨🇳Beijing, Beijing, China
Army Special Medical Center of Peoples Liberation Army
🇨🇳Chongqing, Chongqing, China
Beijing Tongren Hospital affiliated to Capital Medical University
🇨🇳Beijing, Beijing, China
Fujian Medical University Union Hospital
🇨🇳Fuzhou, Fujian, China
Mengchao Hepatobiliary Hospital of Fujian Medical University
🇨🇳Fuzhou, Fujian, China
Sun Yat-Sen University Cancer Center
🇨🇳Guangzhou, Guangdong, China
Affiliated Cancer Hospital of Harbin Medical University
🇨🇳Harbin, Heilongjiang, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
Hunan Cancer Hospital
🇨🇳Changsha, Hunan, China
Subei Peoples Hospital
🇨🇳Yangzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
Jilin Cancer Hospital
🇨🇳Changchun, Jilin, China
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
Linyi Cancer Hospital
🇨🇳Linyi, Shandong, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, Shanghai, China
Shanxi Province Cancer Hospital
🇨🇳Taiyuan, Shanxi, China
West China Hospital of Sichuan University
🇨🇳Chengdu, Sichuan, China
The First Affiliated Hospital of Wenzhou Medical University
🇨🇳Wenzhou, Zhejiang, China
Taizhou Hospital of Zhejiang Province
🇨🇳Taizhou, Zhejiang, China
Beijing Chest Hospital, Capital Medical University
🇨🇳Beijing, China
Tianjin Peoples Hospital
🇨🇳Tianjin, China
Weihai Municipal Hospital
🇨🇳Weihai, China
Fakultni nemocnice Olomouc
🇨🇿Olomouc, Czechia
Masarykuv onkologicky ustav
🇨🇿Brno, Czechia
Nemocnice Agel Ostrava-Vitkovice as
🇨🇿Ostrava-Vitkovice, Czechia
Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon
🇫🇷Grenoble, France
Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon
🇫🇷Lille Cedex, France
Vseobecna fakultni nemocnice v Praze
🇨🇿Praha 2, Czechia
Centre Hospitalier Regional Universitaire de Limoges - Hopital Dupuytren
🇫🇷Limoges Cedex, France
Rigshospitalet
🇩🇰Copenhagen, Denmark
Centre Leon Berard
🇫🇷Lyon, France
Institut Curie
🇫🇷Paris, France
Centre Hospitalier Universitaire Nord
🇫🇷Marseille Cedex 20, France
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
🇫🇷Rennes Cedex 9, France
Centre Hospitalier Lyon Sud
🇫🇷Pierre-Benite cedex, France
Centre Hospitalier Universitaire de Strasbourg - Nouvel Hopital Civil
🇫🇷Strasbourg Cedex, France
Centre Hospitalier Universitaire de Toulouse - Hopital Larrey
🇫🇷Toulouse Cedex 9, France
Gustave Roussy
🇫🇷Villejuif, France
Universitaetsklinikum Dresden
🇩🇪Dresden, Germany
Asklepios Fachkliniken Muenchen Gauting
🇩🇪Gauting, Germany
Universitaetsklinikum Essen
🇩🇪Essen, Germany
LungenClinic Grosshansdorf GmbH
🇩🇪Grosshansdorf, Germany
Universitaetsklinikum Wuerzburg
🇩🇪Wuerzburg, Germany
Robert-Bosch-Krankenhaus
🇩🇪Stuttgart, Germany
Azienda Ospedaliera Universitaria Renato Dulbecco
🇮🇹Catanzaro, Italy
Humanitas Gavazzeni
🇮🇹Bergamo, Italy
Ospedale Policlinico San Martino IRCCS
🇮🇹Genova, Italy
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori
🇮🇹Meldola (FC), Italy
Azienda Ospedaliera Universitaria San Luigi Gonzaga
🇮🇹Orbassano, Italy
Azienda Ospedaliera San Giovanni Addolorata
🇮🇹Roma, Italy
National Hospital Organization Nagoya Medical Center
🇯🇵Nagoya-shi, Aichi, Japan
Aichi Cancer Center
🇯🇵Nagoya-shi, Aichi, Japan
Chungbuk National University Hospital
🇰🇷Cheongju Chungbuk, Korea, Republic of
Gyeongsang National University Hospital
🇰🇷Jinju-si, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Gachon University Gil Hospital
🇰🇷Incheon, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Ulsan University Hospital
🇰🇷Ulsan, Korea, Republic of
The Catholic University of Korea Seoul St Marys Hospital
🇰🇷Seoul, Korea, Republic of
Leids Universitair Medisch Centrum
🇳🇱Leiden, Netherlands
Szpital Specjalistyczny imienia Ludwika Rydygiera w Krakowie Sp zoo
🇵🇱Krakow, Poland
Hospital Cuf Descobertas
🇵🇹Lisboa, Portugal
Hospital Cuf porto
🇵🇹Porto, Portugal
Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca
🇷🇴Cluj Napoca, Romania
Centrul de Oncologie Sf Nectarie SRL
🇷🇴Craiova, Romania
Institutul Regional de Oncologie Iasi
🇷🇴Iasi, Romania
Tan Tock Seng Hospital
🇸🇬Singapore, Singapore
Hospital Regional Universitario de Malaga
🇪🇸Malaga, Andalucía, Spain
Hospital Clinico Universitario Lozano Blesa
🇪🇸Zaragoza, Aragón, Spain
Hospital del Mar
🇪🇸Barcelona, Cataluña, Spain
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Cataluña, Spain
Hospital Universitari Vall d Hebron
🇪🇸Barcelona, Cataluña, Spain
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Madrid, Spain
Complexo Hospitalario Universitario A Coruna Hospital Teresa Herrera
🇪🇸A Coruña, Galicia, Spain
Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hopitaux universitaires de Geneve
🇨🇭Geneve 14, Switzerland
Freiburg Spital
🇨🇭Fribourg, Switzerland
Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi
🇹🇷Ankara, Turkey
Bagcilar Medipol Mega Universite Hastanesi
🇹🇷Istanbul, Turkey
Pamukkale Universitesi Tip Fakultesi Hastanesi
🇹🇷Denizli, Turkey
Ankara Bilkent Sehir Hastanesi
🇹🇷Ankara, Turkey
Ege Universitesi Tip Fakultesi Hastanesi
🇹🇷Izmir, Turkey
Izmir Ekonomi Universitesi Medical Point Hastanesi
🇹🇷Izmir, Turkey
Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi
🇹🇷Istanbul, Turkey
Inonu Universitesi Turgut Ozal Tip Merkezi
🇹🇷Malatya, Turkey
Virginia Commonwealth University
🇺🇸Richmond, Virginia, United States
Sanford Oncology Clinic and Pharmacy
🇺🇸Sioux Falls, South Dakota, United States
Sarawak General Hospital
🇲🇾Kuching, Sarawak, Malaysia
Fujian Cancer Hospital
🇨🇳Fuzhou, China