Fall in core temperature and rewarming in severe infections
Not Applicable
Recruiting
- Conditions
- C01.539.757Sepsis, hypothermiaC23.888.119.565
- Registration Number
- RBR-5gs5w6
- Lead Sponsor
- Instituto de Ciencias Biomedicas -- Universidade de Sao Paulo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Septic patients (Sepsis-3) with core temperature of less than or equal to 35.5ºC. Both sexes; age between 18 and 120 years.
Exclusion Criteria
Patients with extensive burns (greater than 30% of body surface area), metastatic cancer, brain tumor, brain trauma, spinal cord injury, pregnancy. Patients subjected to active cooling within 24 h of the sepsis diagnosis will also be excluded, as will patients subjected to surgery within 24 h of the onset of hypothermia.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Activation of autonomic thermoregulatory effectors, assessed by observation of shivering or sweating by the healthcare professional. Sweating will be measured by a three-point scale: (1) no sign of sweat”; (2) sweat noticed in the forehead”; (3) sweating in several body areas”. Shivering will be measured by a two-point scale: present or not noticeable. This outcome will be monitored hourly for 5 hours, starting at the onset of each episode of hypothermia.
- Secondary Outcome Measures
Name Time Method Thermal discomfort, assessed in non-sedated, conscious patients using a subjective 5-point scale: (1) feeling cold; (2) feeling a little chilly; (3) feeling comfortable; (4) feeling a little warm; (5) feeling hot. This outcome will be monitored hourly for 5 hours, starting at the onset of each episode of hypothermia.