Investigating the efficacy and safety of Plasmapheresis in patients with Moderate to severe COVID-19
Not Applicable
- Conditions
- COVID-19.Covid-19U07.1
- Registration Number
- IRCT20080901001165N58
- Lead Sponsor
- Bagheiat-allah University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Confirmed diagnosis of COVID-19, with either lung CT-Scan result, which is typical for COVID-19 pulmonary involvement,or RT-PCR confirmation.
The patient/Legal guardian has written consciously and freely consent to participate in the study;
The patient has moderate to severe Corona-Virus associated pneumonia;
In the first 48 hours of hospitalization, the patient did not show an improving trend;
In the first 48 hours after his/her inclusion into this study, there is no possibility of discharge from the patient's hospital;
Exclusion Criteria
Multi organ failure;
Pregnancy;
Lactation.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eed to receive ICU service (occurrence of shock, resistant hypoxemia despite receiving oxygen via reservoir oxygen mask, GCS score drops below 12). Timepoint: The patient is monitored every 6 hours, but the results are recorded daily in the checklist. Method of measurement: Physical assessment.
- Secondary Outcome Measures
Name Time Method Mortality rate. Timepoint: 30 days after including the study. Method of measurement: Physical assessment.;Length of hospitalization. Timepoint: The first day and the end of hospitalization. Method of measurement: The hospital record review.;Radiologic response. Timepoint: At the admission, before the discharge. Method of measurement: lung CT-SCAN.;Laboratory changes. Timepoint: Daily. Method of measurement: Blood sample, laboratory analysis.;Fever. Timepoint: Daily. Method of measurement: Thermometer.;Respiratory distress. Timepoint: Daily. Method of measurement: Clinical assessment.;Oxygen saturation without receiving oxygen supplement. Timepoint: It will be measured every 6 hours, but will be recorded daily. Method of measurement: Pulse-oxymetery device.