Serial BNP Testing for Heart Failure Management

Terminated

• Conditions: Heart Failure
• Interventions: Device: BNP assay (Siemens ADVIA Centaur BNP); Other: hidden BNP value

• Registration Number: NCT00622531
• Lead Sponsor: Siemens Healthcare Diagnostics Inc

Brief Summary

The scope of the USE-BNP Trial is to investigate whether knowledge of BNP measurements, in conjunction with clinical assessment, in the outpatient setting can guide the management of therapy in patients with heart failure.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01
• Study First Submitted: 2008-02-14
• Study First Submitted QC: 2008-02-22
• Study First Posted: 2008-02-25
• Primary Completion: 2009-07
• Study Completion: 2009-07
• Status Verified: 2015-11
• Last Update Submitted: 2015-11-16
• Last Update Posted: 2015-11-17

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 108

Inclusion Criteria

• Eligible subjects must be diagnosed with heart failure and have an abnormal BNP reading.

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
BNP Open	BNP assay (Siemens ADVIA Centaur BNP)	Subjects treated based on clinical assessment and knowledge of BNP values
Control	hidden BNP value	Subjects treated based on clinical assessment alone

Primary Outcome Measures

Name	Time	Method
composite endpoint of all cause mortality, hospitalization due to worsening heart failure and administration of IV drug therapy for worsening heart failure.	12 months

Secondary Outcome Measures

Name	Time	Method
Quality of life assessments of two treatment groups	12 months
change in therapy based on BNP usage	12 months
NYHA classifications in the two treatment groups	12 months
number of serious adverse events for the two groups	12 months

Trial Locations

Locations (11)

Bellevue Hospital; 🇺🇸 New York City, New York, United States

Centre Hospitalier de l'Université de Montréal (CHUM) Hôpital Hôtel Dieu; 🇨🇦 Montreal, Quebec, Canada

Palo Alto VA Health Care System; 🇺🇸 Palo Alto, California, United States

The Hudson Valley Heart Center; 🇺🇸 Poughkeepsie, New York, United States

UT Southwestern Medical Center; 🇺🇸 Dallas, Texas, United States

McGill University Health Centre (MUHC) Montreal General Hospital; 🇨🇦 Montreal, Quebec, Canada

Wake Forest University Baptist Medical Center; 🇺🇸 WInston-Salem, North Carolina, United States

Centre Hospitalier Universitaire de Sherbrooke; 🇨🇦 Fleurimont, Quebec, Canada

Virginia Research Institute; 🇺🇸 Danville, Virginia, United States

McGill University Health Centre (MUHC) Royal Victoria Hospital; 🇨🇦 Montreal, Quebec, Canada

Centre de santé et de services sociaux région de Thetford; 🇨🇦 Thetford Mines, Quebec, Canada