Pharmacokinetics and Dynamics of Dexmedetomidine as Adjuvant in TAP Block for Patient Undergoing Lower Abdominal Surgery
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- measure dexmedetomidine level into systemic circulation after local administration
研究概览
简要总结
TAP-block has been shown to be a safe and effective postoperative analgesia method in a variety of general. Dexmedetomidine is a selective α2 agonist with 8 times more affinity for α2 adrenergic receptors compared to clonidine and possesses all the properties of α2 agonist without respiratory depression. Dexmedetomidine has been focus of interest for its broad spectrum (sedative, analgesic and anesthetic sparing) properties, making it a useful and safe adjunct in many clinical applications.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •24 ASA I-II
- •patients (age 18-60 years
- •weight 50-89 kg
排除标准
- •a known allergy to the study drugs
- •significant cardiac
- •respiratory, renal or hepatic diseases
- •bleeding diathesis
研究组 & 干预措施
Dexmedetomidine group
patients were given ultrasound guided TAP-block with 20 ml of 0.5 % bupivacaine + dexmedetomidine 1 μg•kg-1 diluted in 20 ml saline
干预措施: Dexmedetomidine (Drug)
bupivacaine group
patients will given ultrasound guided TAP-block with 20 ml of 0.5 % bupivacaine
干预措施: bupivacaine (Drug)
结局指标
主要结局
measure dexmedetomidine level into systemic circulation after local administration
时间窗: up to 6 hours
assessment of systemic dexmedetomidine level after local administration in TAP block after 15 minutes after giving the block, 30 min, 45 min, 1hrs, 2hrs, 4hrs and 6
次要结局
- total dose of IV PCA morphine consumption in the first 24 h postoperative(24 hours)
研究者
Fatma Adel El sherif,MD
lecturer of anesthesia , ICU and pain management
Assiut University