To diagnose the early decrease in pumping capacity of the heart in patients with liver disease using heart and liver ultrasound.
- Conditions
- Health Condition 1: K740- Hepatic fibrosis
- Registration Number
- CTRI/2024/02/062960
- Lead Sponsor
- Kasturba Medical College Manipal
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Metabolic dysfunction associated steatotic liver disease(MASLD) defined as presence of hepatic steatosis by imaging(USG )or biopsy with atleast one of the cardiometabolic criteria which includes
BMI more than 25 kg/m2 or WC more than 94 cm in males or 80 cm in
females
FBS more than 100, PPBS more than 200,HBA1C more than 5.7 or known case of T2DM
BP more than 130/85mmhg
Plasma triglyceride more than 170 mg/dl
Plasma HDL less than 40mg/dl in males HDL less than 50mg/dl in females
Age less than 65 years and more than 18 years
Average daily alcohol intake less than 20g/day female, less than 40gm/day in males
age more than 65 years and less than 18 years
daily alcohol intake on more than 20g/day in female, more than 40g/day in male
diagnosis of cirrhosis at histology or at clinical ground
presence of hepatocellular carcinoma, ascites, portal hypertension; other comorbid liver diseases (autoimmune hepatitis, HBV, HCV, alcoholic liver disease)
atrial fibrillation; left bundle branch block; history of coronary artery disease (previous myocardial infarction, previous percutaneous coronary intervention or previous coronary artery bypass graft)
moderate-to-severe mitral and/or aortic valve disease; hypertrophic, infiltrative and/or dilated cardiomyopathy
history of congenital heart disease
left ventricular ejection fraction (LVEF)less than 50%
acute coronary syndrome, acute congestive heart failure, acute respiratory failure, acute renal failure
hemodynamic instability
poor echocardiographic acoustic windows (not adequate for appropriate visualization and definition of endocardial border of all cardiac chambers)
lack of consent
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method : Myocardial deformation imaging parameters like GLS using speckle-tracking strain echocardiography in assessing subclinical myocardial dysfunction. <br/ ><br>Liver Stiffness measurement using Fibroscan to assess liver fibrosis. <br/ ><br>Timepoint: Baseline
- Secondary Outcome Measures
Name Time Method ATimepoint: NA