CTRI/2024/02/062960
Not yet recruiting
未知
Myocardial deformation imaging to assess subclinical myocardial dysfunction in patients with metabolic dysfunction associated steatotic liver disease(MASLD) and its correlation with liver stiffness measurement. - NI
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Health Condition 1: K740- Hepatic fibrosis
- Sponsor
- Kasturba Medical College Manipal
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Metabolic dysfunction associated steatotic liver disease(MASLD) defined as presence of hepatic steatosis by imaging(USG )or biopsy with atleast one of the cardiometabolic criteria which includes
- •BMI more than 25 kg/m2 or WC more than 94 cm in males or 80 cm in
- •FBS more than 100, PPBS more than 200,HBA1C more than 5\.7 or known case of T2DM
- •BP more than 130/85mmhg
- •Plasma triglyceride more than 170 mg/dl
- •Plasma HDL less than 40mg/dl in males HDL less than 50mg/dl in females
- •Age less than 65 years and more than 18 years
- •Average daily alcohol intake less than 20g/day female, less than 40gm/day in males
Exclusion Criteria
- •age more than 65 years and less than 18 years
- •daily alcohol intake on more than 20g/day in female, more than 40g/day in male
- •diagnosis of cirrhosis at histology or at clinical ground
- •presence of hepatocellular carcinoma, ascites, portal hypertension; other comorbid liver diseases (autoimmune hepatitis, HBV, HCV, alcoholic liver disease)
- •atrial fibrillation; left bundle branch block; history of coronary artery disease (previous myocardial infarction, previous percutaneous coronary intervention or previous coronary artery bypass graft)
- •moderate\-to\-severe mitral and/or aortic valve disease; hypertrophic, infiltrative and/or dilated cardiomyopathy
- •history of congenital heart disease
- •left ventricular ejection fraction (LVEF)less than 50%
- •acute coronary syndrome, acute congestive heart failure, acute respiratory failure, acute renal failure
- •hemodynamic instability
Outcomes
Primary Outcomes
Not specified
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