Effects of omega-7 sea buckthorn oil capsule on mucous membranes of post-menopausal women [omega 7-tyrniöljykapseleiden käyttö vaihdevuosioireiden, emättimen ja muiden limakalvojen kuivuuden ja virtsatieoireiden hoidossa]
Completed
- Conditions
- Mucosa membrane drynessUrological and Genital DiseasesMenopausal and other perimenopausal disorders
- Registration Number
- ISRCTN91680999
- Lead Sponsor
- Turku University Central Hospital (Finland)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
1. Healthy post-menopausal females aged 55 - 70 years
2. Dryness, itching, pain, burning and/or inflammation in the mucosa of the genital tract
3. Problem of the genital tract mucosa shall not have clear association with severe diseases
Exclusion Criteria
1. Severe diseases and/or receiving systematic medications such as hormone replacement therapy, anti-inflammatory and cholesterol lowering drugs
2. Diabetes
3. Hormonal, renal, haematological, or hepatic dysfunction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Dryness, itching, pain, burning and/or inflammation in the mucosa of the genital tract at baseline, after one and four months of supplementation<br>2. Vaginal PH at baseline, after one and four months of supplementation<br>3. Maturation index of vaginal mucosa at baseline, after one and four months of supplementation
- Secondary Outcome Measures
Name Time Method 1. Plasma total anoxidative capacity at baseline, after one and four months of supplementation<br>2. Plasma isoprostane level at baseline, after one and four months of supplementation<br>3. Plasma C-reactive protein level at baseline, after one and four months of supplementation